Genetic networks in mouse retinal ganglion cells

Felix L. Struebing, Richard K. Lee, Robert Williams, Eldon E. Geisert

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Retinal ganglion cells (RGCs) are the output neuron of the eye, transmitting visual information from the retina through the optic nerve to the brain. The importance of RGCs for vision is demonstrated in blinding diseases where RGCs are lost, such as in glaucoma or after optic nerve injury. In the present study, we hypothesize that normal RGC function is transcriptionally regulated. To test our hypothesis, we examine large retinal expression microarray datasets from recombinant inbred mouse strains in GeneNetwork and define transcriptional networks of RGCs and their subtypes. Two major and functionally distinct transcriptional networks centering around Thy1 and Tubb3 (Class III beta-tubulin) were identified. Each network is independently regulated and modulated by unique genomic loci. Meta-analysis of publically available data confirms that RGC subtypes are differentially susceptible to death, with alpha-RGCs and intrinsically photosensitive RGCs (ipRGCs) being less sensitive to cell death than other RGC subtypes in a mouse model of glaucoma.

Original languageEnglish (US)
Article number169
JournalFrontiers in Genetics
Volume7
Issue numberSEP
DOIs
StatePublished - Sep 28 2016

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Retinal Ganglion Cells
Gene Regulatory Networks
Glaucoma
Optic Nerve Injuries
Inbred Strains Mice
Tubulin
Optic Nerve
Retina
Meta-Analysis
Cell Death
Neurons
Brain

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Genetics(clinical)

Cite this

Genetic networks in mouse retinal ganglion cells. / Struebing, Felix L.; Lee, Richard K.; Williams, Robert; Geisert, Eldon E.

In: Frontiers in Genetics, Vol. 7, No. SEP, 169, 28.09.2016.

Research output: Contribution to journalArticle

Struebing, Felix L. ; Lee, Richard K. ; Williams, Robert ; Geisert, Eldon E. / Genetic networks in mouse retinal ganglion cells. In: Frontiers in Genetics. 2016 ; Vol. 7, No. SEP.
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