Genetic variants associated with lipid profiles in Chinese patients with type 2 diabetes

Xiaomu Kong, Qi Zhao, Xiaoyan Xing, Bo Zhang, Xuelian Zhang, Jing Hong, Wenying Yang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Dyslipidemia is a strong risk factor for cardiovascular disease among patients with type 2 diabetes (T2D). The aim of this study was to identify lipid-related genetic variants in T2D patients of Han Chinese ancestry. Among 4,908 Chinese T2D patients who were not taking lipid-lowering medications, single nucleotide polymorphisms (SNPs) in seven genes previously found to be associated with lipid traits in genome-wide association studies conducted in populations of European ancestry (ABCA1, GCKR, BAZ1B, TOMM40, DOCK7, HNF1A, and HNF4A) were genotyped. After adjusting for multiple covariates, SNPs in ABCA1, GCKR, BAZ1B, TOMM40, and HNF1A were identified as significantly associated with triglyceride levels in T2D patients (P < 0.05). The associations between the SNPs in ABCA1(rs3890182), GCKR (rs780094), and BAZ1B (rs2240466) remained significant even after correction for multiple testing (P = 8.85×10-3, 7.88×10-7, and 2.03×10-6, respectively). BAZ1B (rs2240466) also was associated with the total cholesterol level (P = 4.75×10-2). In addition, SNP rs157580 in TOMM40 was associated with the low-density lipoprotein cholesterol level (P = 6.94×10-3). Our findings confirm that lipid-related genetic loci are associated with lipid profiles in Chinese patients with type 2 diabetes.

Original languageEnglish (US)
Article numbere0135145
JournalPLoS ONE
Volume10
Issue number8
DOIs
StatePublished - Aug 7 2015
Externally publishedYes

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Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Polymorphism
single nucleotide polymorphism
Single Nucleotide Polymorphism
Lipids
Nucleotides
lipids
ancestry
Genes
Genetic Loci
Genome-Wide Association Study
hyperlipidemia
Dyslipidemias
low density lipoprotein cholesterol
LDL Cholesterol
cardiovascular diseases
drug therapy
Triglycerides

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Genetic variants associated with lipid profiles in Chinese patients with type 2 diabetes. / Kong, Xiaomu; Zhao, Qi; Xing, Xiaoyan; Zhang, Bo; Zhang, Xuelian; Hong, Jing; Yang, Wenying.

In: PLoS ONE, Vol. 10, No. 8, e0135145, 07.08.2015.

Research output: Contribution to journalArticle

Kong, Xiaomu ; Zhao, Qi ; Xing, Xiaoyan ; Zhang, Bo ; Zhang, Xuelian ; Hong, Jing ; Yang, Wenying. / Genetic variants associated with lipid profiles in Chinese patients with type 2 diabetes. In: PLoS ONE. 2015 ; Vol. 10, No. 8.
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