Genetically diverse CC-founder mouse strains replicate the human influenza gene expression signature

Husni Elbahesh, Klaus Schughart

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Influenza A viruses (IAV) are zoonotic pathogens that pose a major threat to human and animal health. Influenza virus disease severity is influenced by viral virulence factors as well as individual differences in host response. We analyzed gene expression changes in the blood of infected mice using a previously defined set of signature genes that was derived from changes in the blood transcriptome of IAV-infected human volunteers. We found that the human signature was reproduced well in the founder strains of the Collaborative Cross (CC) mice, thus demonstrating the relevance and importance of mouse experimental model systems for studying human influenza disease.

Original languageEnglish (US)
Article number26437
JournalScientific reports
Volume6
DOIs
StatePublished - May 19 2016

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Transcriptome
Human Influenza
Influenza A virus
Zoonoses
Virulence Factors
Virus Diseases
Orthomyxoviridae
Individuality
Volunteers
Theoretical Models
Gene Expression
Health
Genes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Genetically diverse CC-founder mouse strains replicate the human influenza gene expression signature. / Elbahesh, Husni; Schughart, Klaus.

In: Scientific reports, Vol. 6, 26437, 19.05.2016.

Research output: Contribution to journalArticle

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