Genetic/familial high-risk assessment: Colorectal version 1.2016: Clinical practice guidelines in oncology

Dawn Provenzale, Samir Gupta, Dennis J. Ahnen, Travis Bray, Jamie A. Cannon, Gregory Cooper, Donald S. David, Dayna S. Early, Deborah Erwin, James M. Ford, Francis M. Giardiello, William Grady, Amy L. Halverson, Stanley R. Hamilton, Heather Hampel, Mohammad Ismail, Jason B. Klapman, David W. Larson, Audrey J. Lazenby, Patrick M. LynchRobert J. Mayer, Reid M. Ness, Scott E. Regenbogen, Niloy Jewel Samadder, Moshe Shike, Gideon Steinbach, David Weinberg, Mary Dwyer, Susan Darlow

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.

Original languageEnglish (US)
Pages (from-to)1010-1030
Number of pages21
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume14
Issue number8
DOIs
StatePublished - Aug 1 2016

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Hereditary Nonpolyposis Colorectal Neoplasms
Practice Guidelines
Colorectal Neoplasms
DNA Mismatch Repair
Germ-Line Mutation
Endometrial Neoplasms
Ovarian Neoplasms
Stomach Neoplasms
Guidelines
Population
Genes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Genetic/familial high-risk assessment : Colorectal version 1.2016: Clinical practice guidelines in oncology. / Provenzale, Dawn; Gupta, Samir; Ahnen, Dennis J.; Bray, Travis; Cannon, Jamie A.; Cooper, Gregory; David, Donald S.; Early, Dayna S.; Erwin, Deborah; Ford, James M.; Giardiello, Francis M.; Grady, William; Halverson, Amy L.; Hamilton, Stanley R.; Hampel, Heather; Ismail, Mohammad; Klapman, Jason B.; Larson, David W.; Lazenby, Audrey J.; Lynch, Patrick M.; Mayer, Robert J.; Ness, Reid M.; Regenbogen, Scott E.; Samadder, Niloy Jewel; Shike, Moshe; Steinbach, Gideon; Weinberg, David; Dwyer, Mary; Darlow, Susan.

In: JNCCN Journal of the National Comprehensive Cancer Network, Vol. 14, No. 8, 01.08.2016, p. 1010-1030.

Research output: Contribution to journalArticle

Provenzale, D, Gupta, S, Ahnen, DJ, Bray, T, Cannon, JA, Cooper, G, David, DS, Early, DS, Erwin, D, Ford, JM, Giardiello, FM, Grady, W, Halverson, AL, Hamilton, SR, Hampel, H, Ismail, M, Klapman, JB, Larson, DW, Lazenby, AJ, Lynch, PM, Mayer, RJ, Ness, RM, Regenbogen, SE, Samadder, NJ, Shike, M, Steinbach, G, Weinberg, D, Dwyer, M & Darlow, S 2016, 'Genetic/familial high-risk assessment: Colorectal version 1.2016: Clinical practice guidelines in oncology', JNCCN Journal of the National Comprehensive Cancer Network, vol. 14, no. 8, pp. 1010-1030. https://doi.org/10.6004/jnccn.2016.0108
Provenzale, Dawn ; Gupta, Samir ; Ahnen, Dennis J. ; Bray, Travis ; Cannon, Jamie A. ; Cooper, Gregory ; David, Donald S. ; Early, Dayna S. ; Erwin, Deborah ; Ford, James M. ; Giardiello, Francis M. ; Grady, William ; Halverson, Amy L. ; Hamilton, Stanley R. ; Hampel, Heather ; Ismail, Mohammad ; Klapman, Jason B. ; Larson, David W. ; Lazenby, Audrey J. ; Lynch, Patrick M. ; Mayer, Robert J. ; Ness, Reid M. ; Regenbogen, Scott E. ; Samadder, Niloy Jewel ; Shike, Moshe ; Steinbach, Gideon ; Weinberg, David ; Dwyer, Mary ; Darlow, Susan. / Genetic/familial high-risk assessment : Colorectal version 1.2016: Clinical practice guidelines in oncology. In: JNCCN Journal of the National Comprehensive Cancer Network. 2016 ; Vol. 14, No. 8. pp. 1010-1030.
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