Genetics of body weight in the LXS recombinant inbred mouse strains

Beth Bennett, Phyllis J. Carosone-Link, Lu Lu, Elissa J. Chesler, Thomas E. Johnson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

This is the first phenotypic analysis of 75 new recombinant inbred (RI) strains derived from ILS and ISS progenitors. We analyzed body weight in two independent cohorts of female mice at various ages and in males at 60 days. Body weight is a complex trait which has been mapped in numerous crosses in rodents. The LXS RI strains displayed a large range of weights, transgressing those of the inbred progenitors, supporting the utility of this large panel for mapping traits not selected in the progenitors. Numerous QTLs for body weight mapped in single-and multilocus scans. We assessed replication between these and previously reported QTLs based on overlapping confidence intervals of published QTLs for body weight at 60 days and used meta-analyses to determine combined p values for three QTL regions located on Chromosomes 4, 5, and 11. Strain distribution patterns of microsatellite marker genotypes, weight, and other phenotypes are available on WebQTL (http://www.webqtl.org/search.html) and allow genetic mapping of any heritable quantitative phenotype measured in these strains. We report one such analysis, correlating brain and body weights. Large reference panels of RI strains, such as the LXS, are invaluable for identifying genetic correlations, GXE (Gene X Environment) interactions, and replicating previously identified QTLs.

Original languageEnglish (US)
Pages (from-to)764-774
Number of pages11
JournalMammalian Genome
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2005

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Inbred Strains Mice
Body Weight
Phenotype
Weights and Measures
Gene-Environment Interaction
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 4
Microsatellite Repeats
Meta-Analysis
Rodentia
Genotype
Confidence Intervals
Brain

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Bennett, B., Carosone-Link, P. J., Lu, L., Chesler, E. J., & Johnson, T. E. (2005). Genetics of body weight in the LXS recombinant inbred mouse strains. Mammalian Genome, 16(10), 764-774. https://doi.org/10.1007/s00335-005-0002-6

Genetics of body weight in the LXS recombinant inbred mouse strains. / Bennett, Beth; Carosone-Link, Phyllis J.; Lu, Lu; Chesler, Elissa J.; Johnson, Thomas E.

In: Mammalian Genome, Vol. 16, No. 10, 01.10.2005, p. 764-774.

Research output: Contribution to journalArticle

Bennett, B, Carosone-Link, PJ, Lu, L, Chesler, EJ & Johnson, TE 2005, 'Genetics of body weight in the LXS recombinant inbred mouse strains', Mammalian Genome, vol. 16, no. 10, pp. 764-774. https://doi.org/10.1007/s00335-005-0002-6
Bennett, Beth ; Carosone-Link, Phyllis J. ; Lu, Lu ; Chesler, Elissa J. ; Johnson, Thomas E. / Genetics of body weight in the LXS recombinant inbred mouse strains. In: Mammalian Genome. 2005 ; Vol. 16, No. 10. pp. 764-774.
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