Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians

Joo Yeon Hwang, Xueling Sim, Ying Wu, Jun Liang, Yasuharu Tabara, Cheng Hu, Kazuo Hara, Claudia H.T. Tam, Qiuyin Cai, Qi Zhao, Sunha Jee, Fumihiko Takeuchi, Min Jin Go, Rick Twee Hee Ong, Takayoshi Ohkubo, Young Jin Kim, Rong Zhang, Toshimasa Yamauchi, Wing Yee So, Jirong Long & 46 others Dongfeng Gu, Nanette R. Lee, Soriul Kim, Tomohiro Katsuya, Ji Hee Oh, Jianjun Liu, Satoshi Umemura, Yeon Jung Kim, Feng Jiang, Shiro Maeda, Juliana C.N. Chan, Wei Lu, James E. Hixson, Linda S. Adair, Keum Ji Jung, Toru Nabika, Jae Bum Bae, Mi Hee Lee, Mark Seielstad, Terri L. Young, Yik Ying Teo, Yoshikuni Kita, Naoyuki Takashima, Haruhiko Osawa, So Hyun Lee, Min Ho Shin, Dong Hoon Shin, Bo Youl Choi, Jiajun Shi, Yu Tang Gao, Yong Bing Xiang, Wei Zheng, Norihiro Kato, Miwuk Yoon, Jiang He, Xiao Ou Shu, Ronald C.W. Ma, Takashi Kadowaki, Weiping Jia, Tetsuro Miki, Lu Qi, E. Shyong Tai, Karen L. Mohlke, Bok Ghee Han, Yoon Shin Cho, Bong Jo Kim

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalDiabetes
Volume64
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Genome-Wide Association Study
Meta-Analysis
Fasting
Glucose
Genome
Metabolic Diseases
Population

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. / Hwang, Joo Yeon; Sim, Xueling; Wu, Ying; Liang, Jun; Tabara, Yasuharu; Hu, Cheng; Hara, Kazuo; Tam, Claudia H.T.; Cai, Qiuyin; Zhao, Qi; Jee, Sunha; Takeuchi, Fumihiko; Go, Min Jin; Ong, Rick Twee Hee; Ohkubo, Takayoshi; Kim, Young Jin; Zhang, Rong; Yamauchi, Toshimasa; So, Wing Yee; Long, Jirong; Gu, Dongfeng; Lee, Nanette R.; Kim, Soriul; Katsuya, Tomohiro; Oh, Ji Hee; Liu, Jianjun; Umemura, Satoshi; Kim, Yeon Jung; Jiang, Feng; Maeda, Shiro; Chan, Juliana C.N.; Lu, Wei; Hixson, James E.; Adair, Linda S.; Jung, Keum Ji; Nabika, Toru; Bae, Jae Bum; Lee, Mi Hee; Seielstad, Mark; Young, Terri L.; Teo, Yik Ying; Kita, Yoshikuni; Takashima, Naoyuki; Osawa, Haruhiko; Lee, So Hyun; Shin, Min Ho; Shin, Dong Hoon; Choi, Bo Youl; Shi, Jiajun; Gao, Yu Tang; Xiang, Yong Bing; Zheng, Wei; Kato, Norihiro; Yoon, Miwuk; He, Jiang; Shu, Xiao Ou; Ma, Ronald C.W.; Kadowaki, Takashi; Jia, Weiping; Miki, Tetsuro; Qi, Lu; Tai, E. Shyong; Mohlke, Karen L.; Han, Bok Ghee; Cho, Yoon Shin; Kim, Bong Jo.

In: Diabetes, Vol. 64, No. 1, 01.01.2015, p. 291-298.

Research output: Contribution to journalArticle

Hwang, JY, Sim, X, Wu, Y, Liang, J, Tabara, Y, Hu, C, Hara, K, Tam, CHT, Cai, Q, Zhao, Q, Jee, S, Takeuchi, F, Go, MJ, Ong, RTH, Ohkubo, T, Kim, YJ, Zhang, R, Yamauchi, T, So, WY, Long, J, Gu, D, Lee, NR, Kim, S, Katsuya, T, Oh, JH, Liu, J, Umemura, S, Kim, YJ, Jiang, F, Maeda, S, Chan, JCN, Lu, W, Hixson, JE, Adair, LS, Jung, KJ, Nabika, T, Bae, JB, Lee, MH, Seielstad, M, Young, TL, Teo, YY, Kita, Y, Takashima, N, Osawa, H, Lee, SH, Shin, MH, Shin, DH, Choi, BY, Shi, J, Gao, YT, Xiang, YB, Zheng, W, Kato, N, Yoon, M, He, J, Shu, XO, Ma, RCW, Kadowaki, T, Jia, W, Miki, T, Qi, L, Tai, ES, Mohlke, KL, Han, BG, Cho, YS & Kim, BJ 2015, 'Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians', Diabetes, vol. 64, no. 1, pp. 291-298. https://doi.org/10.2337/db14-0563
Hwang, Joo Yeon ; Sim, Xueling ; Wu, Ying ; Liang, Jun ; Tabara, Yasuharu ; Hu, Cheng ; Hara, Kazuo ; Tam, Claudia H.T. ; Cai, Qiuyin ; Zhao, Qi ; Jee, Sunha ; Takeuchi, Fumihiko ; Go, Min Jin ; Ong, Rick Twee Hee ; Ohkubo, Takayoshi ; Kim, Young Jin ; Zhang, Rong ; Yamauchi, Toshimasa ; So, Wing Yee ; Long, Jirong ; Gu, Dongfeng ; Lee, Nanette R. ; Kim, Soriul ; Katsuya, Tomohiro ; Oh, Ji Hee ; Liu, Jianjun ; Umemura, Satoshi ; Kim, Yeon Jung ; Jiang, Feng ; Maeda, Shiro ; Chan, Juliana C.N. ; Lu, Wei ; Hixson, James E. ; Adair, Linda S. ; Jung, Keum Ji ; Nabika, Toru ; Bae, Jae Bum ; Lee, Mi Hee ; Seielstad, Mark ; Young, Terri L. ; Teo, Yik Ying ; Kita, Yoshikuni ; Takashima, Naoyuki ; Osawa, Haruhiko ; Lee, So Hyun ; Shin, Min Ho ; Shin, Dong Hoon ; Choi, Bo Youl ; Shi, Jiajun ; Gao, Yu Tang ; Xiang, Yong Bing ; Zheng, Wei ; Kato, Norihiro ; Yoon, Miwuk ; He, Jiang ; Shu, Xiao Ou ; Ma, Ronald C.W. ; Kadowaki, Takashi ; Jia, Weiping ; Miki, Tetsuro ; Qi, Lu ; Tai, E. Shyong ; Mohlke, Karen L. ; Han, Bok Ghee ; Cho, Yoon Shin ; Kim, Bong Jo. / Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. In: Diabetes. 2015 ; Vol. 64, No. 1. pp. 291-298.
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abstract = "Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.",
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AU - Hwang, Joo Yeon

AU - Sim, Xueling

AU - Wu, Ying

AU - Liang, Jun

AU - Tabara, Yasuharu

AU - Hu, Cheng

AU - Hara, Kazuo

AU - Tam, Claudia H.T.

AU - Cai, Qiuyin

AU - Zhao, Qi

AU - Jee, Sunha

AU - Takeuchi, Fumihiko

AU - Go, Min Jin

AU - Ong, Rick Twee Hee

AU - Ohkubo, Takayoshi

AU - Kim, Young Jin

AU - Zhang, Rong

AU - Yamauchi, Toshimasa

AU - So, Wing Yee

AU - Long, Jirong

AU - Gu, Dongfeng

AU - Lee, Nanette R.

AU - Kim, Soriul

AU - Katsuya, Tomohiro

AU - Oh, Ji Hee

AU - Liu, Jianjun

AU - Umemura, Satoshi

AU - Kim, Yeon Jung

AU - Jiang, Feng

AU - Maeda, Shiro

AU - Chan, Juliana C.N.

AU - Lu, Wei

AU - Hixson, James E.

AU - Adair, Linda S.

AU - Jung, Keum Ji

AU - Nabika, Toru

AU - Bae, Jae Bum

AU - Lee, Mi Hee

AU - Seielstad, Mark

AU - Young, Terri L.

AU - Teo, Yik Ying

AU - Kita, Yoshikuni

AU - Takashima, Naoyuki

AU - Osawa, Haruhiko

AU - Lee, So Hyun

AU - Shin, Min Ho

AU - Shin, Dong Hoon

AU - Choi, Bo Youl

AU - Shi, Jiajun

AU - Gao, Yu Tang

AU - Xiang, Yong Bing

AU - Zheng, Wei

AU - Kato, Norihiro

AU - Yoon, Miwuk

AU - He, Jiang

AU - Shu, Xiao Ou

AU - Ma, Ronald C.W.

AU - Kadowaki, Takashi

AU - Jia, Weiping

AU - Miki, Tetsuro

AU - Qi, Lu

AU - Tai, E. Shyong

AU - Mohlke, Karen L.

AU - Han, Bok Ghee

AU - Cho, Yoon Shin

AU - Kim, Bong Jo

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