Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci

Tanika N. Kelly, Fumihiko Takeuchi, Yasuharu Tabara, Todd L. Edwards, Young Jin Kim, Peng Chen, Huaixing Li, Ying Wu, Chi Fan Yang, Yonghong Zhang, Dongfeng Gu, Tomohiro Katsuya, Takayoshi Ohkubo, Yu Tang Gao, Min Jin Go, Yik Ying Teo, Ling Lu, Nanette R. Lee, Li Ching Chang, Hao Peng & 37 others Qi Zhao, Eitaro Nakashima, Yoshikuni Kita, Xiao Ou Shu, Nam Hee Kim, E. Shyong Tai, Yiqin Wang, Linda S. Adair, Chien Hsiun Chen, Shihiu Zhang, Changwei Li, Toru Nabika, Satoshi Umemura, Qiuyin Cai, Yoon Shin Cho, Tien Yin Wong, Jingwen Zhu, Jer Yuarn Wu, Xin Gao, James E. Hixson, Hui Cai, Juyoung Lee, Ching Yu Cheng, Dabeeru C. Rao, Yong Bing Xiang, Myeong Chan Cho, Bok Ghee Han, Aili Wang, Fuu Jen Tsai, Karen Mohlke, Xu Lin, Mohammad Kamran Ikram, Jong Young Lee, Wei Zheng, Miki Tetsuro, Norihiro Kato, Jiang He

Research output: Contribution to journalArticle

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Abstract

We conducted a genome-wide association study meta-analysis of mean arterial pressure and pulse pressure among 26 600 East Asian participants (stage 1) followed by replication study of up to 28 783 participants (stage 2). For novel loci, statistical significance was determined by a P<5.0×10 in joint analysis of stage 1 and stage 2 data. For loci reported by the previous mean arterial and pulse pressure genome-wide association study meta-analysis in Europeans, evidence of transethnic replication was determined by consistency in effect direction and a Bonferroni-corrected P<1.4×10. No novel loci were identified by the current study. Five independent mean arterial pressure variants demonstrated robust evidence for transethnic replication including rs17249754 at ATP2B1 (P=7.5×10), rs2681492 at ATP2B1 (P=3.4×10), rs11191593 at NT5C2 (1.1×10), rs3824755 at CYP17A1 (P=1.2×10), and rs13149993 at FGF5 (P=2.4×10). Two additional variants showed suggestive evidence of transethnic replication (consistency in effect direction and P<0.05), including rs319690 at MAP4 (P=0.014) and rs1173771 at NPR3 (P=0.018). For pulse pressure, robust evidence of replication was identified for 2 independent variants, including rs17249754 at ATP2B1 (P=1.2×10) and rs11191593 at NT5C2 (P=1.1×10), with suggestive evidence of replication among an additional 2 variants including rs3824755 at CYP17A1 (P=6.1×10) and rs2681492 at ATP2B1 (P=9.0×10). Replicated variants demonstrated consistency in effect sizes between East Asian and European samples, with effect size differences ranging from 0.03 to 0.24 mm Hg for mean arterial pressure and from 0.03 to 0.21 mm Hg for pulse pressure. In conclusion, we present the first evidence of transethnic replication of several mean arterial and pulse pressure loci in an East Asian population.

Original languageEnglish (US)
Pages (from-to)853-859
Number of pages7
JournalHypertension
Volume62
Issue number5
DOIs
StatePublished - Jan 1 2013

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Genome-Wide Association Study
Meta-Analysis
Arterial Pressure
Blood Pressure
Population
Direction compound

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci. / Kelly, Tanika N.; Takeuchi, Fumihiko; Tabara, Yasuharu; Edwards, Todd L.; Kim, Young Jin; Chen, Peng; Li, Huaixing; Wu, Ying; Yang, Chi Fan; Zhang, Yonghong; Gu, Dongfeng; Katsuya, Tomohiro; Ohkubo, Takayoshi; Gao, Yu Tang; Go, Min Jin; Teo, Yik Ying; Lu, Ling; Lee, Nanette R.; Chang, Li Ching; Peng, Hao; Zhao, Qi; Nakashima, Eitaro; Kita, Yoshikuni; Shu, Xiao Ou; Kim, Nam Hee; Tai, E. Shyong; Wang, Yiqin; Adair, Linda S.; Chen, Chien Hsiun; Zhang, Shihiu; Li, Changwei; Nabika, Toru; Umemura, Satoshi; Cai, Qiuyin; Cho, Yoon Shin; Wong, Tien Yin; Zhu, Jingwen; Wu, Jer Yuarn; Gao, Xin; Hixson, James E.; Cai, Hui; Lee, Juyoung; Cheng, Ching Yu; Rao, Dabeeru C.; Xiang, Yong Bing; Cho, Myeong Chan; Han, Bok Ghee; Wang, Aili; Tsai, Fuu Jen; Mohlke, Karen; Lin, Xu; Ikram, Mohammad Kamran; Lee, Jong Young; Zheng, Wei; Tetsuro, Miki; Kato, Norihiro; He, Jiang.

In: Hypertension, Vol. 62, No. 5, 01.01.2013, p. 853-859.

Research output: Contribution to journalArticle

Kelly, TN, Takeuchi, F, Tabara, Y, Edwards, TL, Kim, YJ, Chen, P, Li, H, Wu, Y, Yang, CF, Zhang, Y, Gu, D, Katsuya, T, Ohkubo, T, Gao, YT, Go, MJ, Teo, YY, Lu, L, Lee, NR, Chang, LC, Peng, H, Zhao, Q, Nakashima, E, Kita, Y, Shu, XO, Kim, NH, Tai, ES, Wang, Y, Adair, LS, Chen, CH, Zhang, S, Li, C, Nabika, T, Umemura, S, Cai, Q, Cho, YS, Wong, TY, Zhu, J, Wu, JY, Gao, X, Hixson, JE, Cai, H, Lee, J, Cheng, CY, Rao, DC, Xiang, YB, Cho, MC, Han, BG, Wang, A, Tsai, FJ, Mohlke, K, Lin, X, Ikram, MK, Lee, JY, Zheng, W, Tetsuro, M, Kato, N & He, J 2013, 'Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci', Hypertension, vol. 62, no. 5, pp. 853-859. https://doi.org/10.1161/HYPERTENSIONAHA.113.01148
Kelly, Tanika N. ; Takeuchi, Fumihiko ; Tabara, Yasuharu ; Edwards, Todd L. ; Kim, Young Jin ; Chen, Peng ; Li, Huaixing ; Wu, Ying ; Yang, Chi Fan ; Zhang, Yonghong ; Gu, Dongfeng ; Katsuya, Tomohiro ; Ohkubo, Takayoshi ; Gao, Yu Tang ; Go, Min Jin ; Teo, Yik Ying ; Lu, Ling ; Lee, Nanette R. ; Chang, Li Ching ; Peng, Hao ; Zhao, Qi ; Nakashima, Eitaro ; Kita, Yoshikuni ; Shu, Xiao Ou ; Kim, Nam Hee ; Tai, E. Shyong ; Wang, Yiqin ; Adair, Linda S. ; Chen, Chien Hsiun ; Zhang, Shihiu ; Li, Changwei ; Nabika, Toru ; Umemura, Satoshi ; Cai, Qiuyin ; Cho, Yoon Shin ; Wong, Tien Yin ; Zhu, Jingwen ; Wu, Jer Yuarn ; Gao, Xin ; Hixson, James E. ; Cai, Hui ; Lee, Juyoung ; Cheng, Ching Yu ; Rao, Dabeeru C. ; Xiang, Yong Bing ; Cho, Myeong Chan ; Han, Bok Ghee ; Wang, Aili ; Tsai, Fuu Jen ; Mohlke, Karen ; Lin, Xu ; Ikram, Mohammad Kamran ; Lee, Jong Young ; Zheng, Wei ; Tetsuro, Miki ; Kato, Norihiro ; He, Jiang. / Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci. In: Hypertension. 2013 ; Vol. 62, No. 5. pp. 853-859.
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TY - JOUR

T1 - Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci

AU - Kelly, Tanika N.

AU - Takeuchi, Fumihiko

AU - Tabara, Yasuharu

AU - Edwards, Todd L.

AU - Kim, Young Jin

AU - Chen, Peng

AU - Li, Huaixing

AU - Wu, Ying

AU - Yang, Chi Fan

AU - Zhang, Yonghong

AU - Gu, Dongfeng

AU - Katsuya, Tomohiro

AU - Ohkubo, Takayoshi

AU - Gao, Yu Tang

AU - Go, Min Jin

AU - Teo, Yik Ying

AU - Lu, Ling

AU - Lee, Nanette R.

AU - Chang, Li Ching

AU - Peng, Hao

AU - Zhao, Qi

AU - Nakashima, Eitaro

AU - Kita, Yoshikuni

AU - Shu, Xiao Ou

AU - Kim, Nam Hee

AU - Tai, E. Shyong

AU - Wang, Yiqin

AU - Adair, Linda S.

AU - Chen, Chien Hsiun

AU - Zhang, Shihiu

AU - Li, Changwei

AU - Nabika, Toru

AU - Umemura, Satoshi

AU - Cai, Qiuyin

AU - Cho, Yoon Shin

AU - Wong, Tien Yin

AU - Zhu, Jingwen

AU - Wu, Jer Yuarn

AU - Gao, Xin

AU - Hixson, James E.

AU - Cai, Hui

AU - Lee, Juyoung

AU - Cheng, Ching Yu

AU - Rao, Dabeeru C.

AU - Xiang, Yong Bing

AU - Cho, Myeong Chan

AU - Han, Bok Ghee

AU - Wang, Aili

AU - Tsai, Fuu Jen

AU - Mohlke, Karen

AU - Lin, Xu

AU - Ikram, Mohammad Kamran

AU - Lee, Jong Young

AU - Zheng, Wei

AU - Tetsuro, Miki

AU - Kato, Norihiro

AU - He, Jiang

PY - 2013/1/1

Y1 - 2013/1/1

N2 - We conducted a genome-wide association study meta-analysis of mean arterial pressure and pulse pressure among 26 600 East Asian participants (stage 1) followed by replication study of up to 28 783 participants (stage 2). For novel loci, statistical significance was determined by a P<5.0×10 in joint analysis of stage 1 and stage 2 data. For loci reported by the previous mean arterial and pulse pressure genome-wide association study meta-analysis in Europeans, evidence of transethnic replication was determined by consistency in effect direction and a Bonferroni-corrected P<1.4×10. No novel loci were identified by the current study. Five independent mean arterial pressure variants demonstrated robust evidence for transethnic replication including rs17249754 at ATP2B1 (P=7.5×10), rs2681492 at ATP2B1 (P=3.4×10), rs11191593 at NT5C2 (1.1×10), rs3824755 at CYP17A1 (P=1.2×10), and rs13149993 at FGF5 (P=2.4×10). Two additional variants showed suggestive evidence of transethnic replication (consistency in effect direction and P<0.05), including rs319690 at MAP4 (P=0.014) and rs1173771 at NPR3 (P=0.018). For pulse pressure, robust evidence of replication was identified for 2 independent variants, including rs17249754 at ATP2B1 (P=1.2×10) and rs11191593 at NT5C2 (P=1.1×10), with suggestive evidence of replication among an additional 2 variants including rs3824755 at CYP17A1 (P=6.1×10) and rs2681492 at ATP2B1 (P=9.0×10). Replicated variants demonstrated consistency in effect sizes between East Asian and European samples, with effect size differences ranging from 0.03 to 0.24 mm Hg for mean arterial pressure and from 0.03 to 0.21 mm Hg for pulse pressure. In conclusion, we present the first evidence of transethnic replication of several mean arterial and pulse pressure loci in an East Asian population.

AB - We conducted a genome-wide association study meta-analysis of mean arterial pressure and pulse pressure among 26 600 East Asian participants (stage 1) followed by replication study of up to 28 783 participants (stage 2). For novel loci, statistical significance was determined by a P<5.0×10 in joint analysis of stage 1 and stage 2 data. For loci reported by the previous mean arterial and pulse pressure genome-wide association study meta-analysis in Europeans, evidence of transethnic replication was determined by consistency in effect direction and a Bonferroni-corrected P<1.4×10. No novel loci were identified by the current study. Five independent mean arterial pressure variants demonstrated robust evidence for transethnic replication including rs17249754 at ATP2B1 (P=7.5×10), rs2681492 at ATP2B1 (P=3.4×10), rs11191593 at NT5C2 (1.1×10), rs3824755 at CYP17A1 (P=1.2×10), and rs13149993 at FGF5 (P=2.4×10). Two additional variants showed suggestive evidence of transethnic replication (consistency in effect direction and P<0.05), including rs319690 at MAP4 (P=0.014) and rs1173771 at NPR3 (P=0.018). For pulse pressure, robust evidence of replication was identified for 2 independent variants, including rs17249754 at ATP2B1 (P=1.2×10) and rs11191593 at NT5C2 (P=1.1×10), with suggestive evidence of replication among an additional 2 variants including rs3824755 at CYP17A1 (P=6.1×10) and rs2681492 at ATP2B1 (P=9.0×10). Replicated variants demonstrated consistency in effect sizes between East Asian and European samples, with effect size differences ranging from 0.03 to 0.24 mm Hg for mean arterial pressure and from 0.03 to 0.21 mm Hg for pulse pressure. In conclusion, we present the first evidence of transethnic replication of several mean arterial and pulse pressure loci in an East Asian population.

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