Genome-wide linkage scan for prostate cancer susceptibility in Finland

Evidence for a novel locus on 2q37.3 and confirmation of signal on 17q21-q22

Cheryl D. Cropp, Claire Simpson, Tiina Wahlfors, Nati Ha, Asha George, Marypat S. Jones, Ursula Harper, Damaris Ponciano-Jackson, Tiffany A. Green, Teuvo L.J. Tammela, Joan Bailey-Wilson, Johanna Schleutker

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Genome-wide linkage studies have been used to localize rare and highly penetrant prostate cancer (PRCA) susceptibility genes. Linkage studies performed in different ethnic backgrounds and populations have been somewhat disparate, resulting in multiple, often irreproducible signals because of genetic heterogeneity and high sporadic background of the disease. Our first genome-wide linkage study and subsequent fine-mapping study of Finnish hereditary prostate cancer (HPC) families gave evidence of linkage to one region. Here, we conducted subsequent scans with microsatellites and SNPs in a total of 69 Finnish HPC families. GENEHUNTER-PLUS was used for parametric and nonparametric analyses. Our microsatellite genome-wide linkage study provided evidence of linkage to 17q12-q23, with a heterogeneity LOD (HLOD) score of 3.14 in a total of 54 of the 69 families. Genome-wide SNP analysis of 59 of the 69 families gave a highest HLOD score of 3.40 at 2q37.3 under a dominant high penetrance model. Analyzing all 69 families by combining microsatellite and SNP maps also yielded HLOD scores of > 3.3 in two regions (2q37.3 and 17q12-q21.3). These significant linkage peaks on chromosome 2 and 17 confirm previous linkage evidence of a locus on 17q from other populations and provide a basis for continued research into genetic factors involved in PRCA. Fine-mapping analysis of these regions is ongoing and candidate genes at linked loci are currently under analysis.

Original languageEnglish (US)
Pages (from-to)2400-2407
Number of pages8
JournalInternational Journal of Cancer
Volume129
Issue number10
DOIs
StatePublished - Nov 15 2011

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Finland
Prostatic Neoplasms
Genome
Microsatellite Repeats
Single Nucleotide Polymorphism
Genetic Research
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 2
Genetic Heterogeneity
Penetrance
Neoplasm Genes
Population
Genes
Familial Prostate cancer

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Genome-wide linkage scan for prostate cancer susceptibility in Finland : Evidence for a novel locus on 2q37.3 and confirmation of signal on 17q21-q22. / Cropp, Cheryl D.; Simpson, Claire; Wahlfors, Tiina; Ha, Nati; George, Asha; Jones, Marypat S.; Harper, Ursula; Ponciano-Jackson, Damaris; Green, Tiffany A.; Tammela, Teuvo L.J.; Bailey-Wilson, Joan; Schleutker, Johanna.

In: International Journal of Cancer, Vol. 129, No. 10, 15.11.2011, p. 2400-2407.

Research output: Contribution to journalArticle

Cropp, CD, Simpson, C, Wahlfors, T, Ha, N, George, A, Jones, MS, Harper, U, Ponciano-Jackson, D, Green, TA, Tammela, TLJ, Bailey-Wilson, J & Schleutker, J 2011, 'Genome-wide linkage scan for prostate cancer susceptibility in Finland: Evidence for a novel locus on 2q37.3 and confirmation of signal on 17q21-q22', International Journal of Cancer, vol. 129, no. 10, pp. 2400-2407. https://doi.org/10.1002/ijc.25906
Cropp, Cheryl D. ; Simpson, Claire ; Wahlfors, Tiina ; Ha, Nati ; George, Asha ; Jones, Marypat S. ; Harper, Ursula ; Ponciano-Jackson, Damaris ; Green, Tiffany A. ; Tammela, Teuvo L.J. ; Bailey-Wilson, Joan ; Schleutker, Johanna. / Genome-wide linkage scan for prostate cancer susceptibility in Finland : Evidence for a novel locus on 2q37.3 and confirmation of signal on 17q21-q22. In: International Journal of Cancer. 2011 ; Vol. 129, No. 10. pp. 2400-2407.
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