Genomes to life "Center for Molecular and Cellular Systems"

A research program for identification and characterization of protein complexes

Michelle V. Buchanan, Frank W. Larimer, H. Steven Wiley, Stephen Kennel, Thomas J. Squier, J. Michael Ramsey, Karin D. Rodland, Gregory B. Hurst, Richard D. Smith, Ying Xu, David Dixon, Mitchel J. Doktycz, Steve Colson, Ray Gesteland, Carol Giometti, Malin Young, Michael Giddings

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Goal 1 of Department of Energy's Genomes to Life (GTL) program seeks to identify and characterize the complete set of protein complexes within a cell. Goal 1 forms the foundation necessary to accomplish the other objectives of the GTL program, which focus on gene regulatory networks and molecular level characterization of interactions in microbial communities. Together this information would allow cells and their components to be understood in sufficient detail to predict, test and understand the responses of a biological system to its environment. The Center for Molecular and Cellular Systems has been established to identify and characterize protein complexes using high through-put analytical technologies. A dynamic research program is being developed that supports the goals of the Center by focusing on the development new capabilities for sample preparation and complex separations, molecular level identification of the protein complexes by mass spectrometry, characterization of the complexes in living cells by imaging techniques, and bioinformatics and computational tools for the collection and interpretation of data and formation of databases and tools to allow the data to be shared by the biological community.

Original languageEnglish (US)
Pages (from-to)287-303
Number of pages17
JournalOMICS A Journal of Integrative Biology
Volume6
Issue number4
DOIs
StatePublished - Jan 1 2002

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Genes
Genome
Research
Microbial Interactions
Biota
Proteins
Gene Regulatory Networks
Biological systems
Cellular Structures
Bioinformatics
Computational Biology
Mass spectrometry
Mass Spectrometry
Cells
Databases
Technology
Imaging techniques

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics

Cite this

Genomes to life "Center for Molecular and Cellular Systems" : A research program for identification and characterization of protein complexes. / Buchanan, Michelle V.; Larimer, Frank W.; Wiley, H. Steven; Kennel, Stephen; Squier, Thomas J.; Ramsey, J. Michael; Rodland, Karin D.; Hurst, Gregory B.; Smith, Richard D.; Xu, Ying; Dixon, David; Doktycz, Mitchel J.; Colson, Steve; Gesteland, Ray; Giometti, Carol; Young, Malin; Giddings, Michael.

In: OMICS A Journal of Integrative Biology, Vol. 6, No. 4, 01.01.2002, p. 287-303.

Research output: Contribution to journalReview article

Buchanan, MV, Larimer, FW, Wiley, HS, Kennel, S, Squier, TJ, Ramsey, JM, Rodland, KD, Hurst, GB, Smith, RD, Xu, Y, Dixon, D, Doktycz, MJ, Colson, S, Gesteland, R, Giometti, C, Young, M & Giddings, M 2002, 'Genomes to life "Center for Molecular and Cellular Systems": A research program for identification and characterization of protein complexes', OMICS A Journal of Integrative Biology, vol. 6, no. 4, pp. 287-303. https://doi.org/10.1089/153623102321112737
Buchanan, Michelle V. ; Larimer, Frank W. ; Wiley, H. Steven ; Kennel, Stephen ; Squier, Thomas J. ; Ramsey, J. Michael ; Rodland, Karin D. ; Hurst, Gregory B. ; Smith, Richard D. ; Xu, Ying ; Dixon, David ; Doktycz, Mitchel J. ; Colson, Steve ; Gesteland, Ray ; Giometti, Carol ; Young, Malin ; Giddings, Michael. / Genomes to life "Center for Molecular and Cellular Systems" : A research program for identification and characterization of protein complexes. In: OMICS A Journal of Integrative Biology. 2002 ; Vol. 6, No. 4. pp. 287-303.
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