Genomic influences on alcohol problems in a population-based sample of young adults

Alexis C. Edwards, Fazil Aliev, Aaron Wolen, Jessica E. Salvatore, Charles O. Gardner, George Mcmahon, David M. Evans, John Macleod, Matthew Hickman, Danielle M. Dick, Kenneth S. Kendler

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Aims: Alcohol problems (AP) contribute substantially to the global disease burden. Twin and family studies suggest that AP are genetically influenced, although few studies have identified variants or genes that are robustly associated with risk. This study identifies genetic and genomic influences on AP during young adulthood, which is often when drinking habits are established. Design: We conducted a genome-wide association study of AP. We further conducted gene-based tests, gene ontology analyses and functional genomic enrichment analyses to assess genomic factors beyond single variants that are relevant to AP. Setting: The Avon Longitudinal Study of Parents and Children, a large population-based study of a UK birth cohort. Participants: Genetic and phenotypical data were available for 4304 participants. Measurements: The AP phenotype was a factor score derived from items from the Alcohol Use Disorders Identification Test, symptoms of DSM-IV alcohol dependence, and three additional problem-related items. Findings: One variant met genome-wide significance criteria. Four out of 22880 genes subjected to gene-based analyses survived a stringent significance threshold (q<0.05); none of these have been implicated previously in alcohol-related phenotypes. Several biologically plausible gene ontologies were statistically over-represented among implicated single nucleotide polymorphisms (SNPs). SNPs on the Illumina 550K SNP chip accounted for ~5% of the phenotypical variance in AP. Conclusions: Genetic and genomic factors appear to play a role in alcohol problems in young adults. Genes involved in nervous system-related processes, such as signal transduction and neurogenesis, potentially contribute to liability to alcohol problems, as do genes expressed in non-brain tissues.

Original languageEnglish (US)
Pages (from-to)461-470
Number of pages10
JournalAddiction
Volume110
Issue number3
DOIs
StatePublished - Mar 1 2015

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Young Adult
Alcohols
Population
Genes
Single Nucleotide Polymorphism
Gene Ontology
Phenotype
Twin Studies
Genome-Wide Association Study
Neurogenesis
Diagnostic and Statistical Manual of Mental Disorders
Nervous System
Alcoholism
Drinking
Habits
Longitudinal Studies
Signal Transduction
Parents
Parturition
Genome

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Psychiatry and Mental health

Cite this

Edwards, A. C., Aliev, F., Wolen, A., Salvatore, J. E., Gardner, C. O., Mcmahon, G., ... Kendler, K. S. (2015). Genomic influences on alcohol problems in a population-based sample of young adults. Addiction, 110(3), 461-470. https://doi.org/10.1111/add.12822

Genomic influences on alcohol problems in a population-based sample of young adults. / Edwards, Alexis C.; Aliev, Fazil; Wolen, Aaron; Salvatore, Jessica E.; Gardner, Charles O.; Mcmahon, George; Evans, David M.; Macleod, John; Hickman, Matthew; Dick, Danielle M.; Kendler, Kenneth S.

In: Addiction, Vol. 110, No. 3, 01.03.2015, p. 461-470.

Research output: Contribution to journalArticle

Edwards, AC, Aliev, F, Wolen, A, Salvatore, JE, Gardner, CO, Mcmahon, G, Evans, DM, Macleod, J, Hickman, M, Dick, DM & Kendler, KS 2015, 'Genomic influences on alcohol problems in a population-based sample of young adults', Addiction, vol. 110, no. 3, pp. 461-470. https://doi.org/10.1111/add.12822
Edwards AC, Aliev F, Wolen A, Salvatore JE, Gardner CO, Mcmahon G et al. Genomic influences on alcohol problems in a population-based sample of young adults. Addiction. 2015 Mar 1;110(3):461-470. https://doi.org/10.1111/add.12822
Edwards, Alexis C. ; Aliev, Fazil ; Wolen, Aaron ; Salvatore, Jessica E. ; Gardner, Charles O. ; Mcmahon, George ; Evans, David M. ; Macleod, John ; Hickman, Matthew ; Dick, Danielle M. ; Kendler, Kenneth S. / Genomic influences on alcohol problems in a population-based sample of young adults. In: Addiction. 2015 ; Vol. 110, No. 3. pp. 461-470.
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