Genomic organization of the human procollagen α1 (II) collagen gene

Min‐Chi ‐C HUANG, Jerome M. SEYER, James P. THOMPSON, Dominic G. SPINELLA, Kathy S.E. CHEAH, Andrew Kang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The nucleotide sequence of the human procollagen α1 (II) collagen gene extending from within the first intron through exon 15, and part of the 15th intron has been determined. This sequence analysis (7056 bases) identifies the intron/exon organization of the region of this gene encoding the N‐propeptide and part of the triple‐helical domain. Structural comparison of this with the genes of other human fibrillar collagens shows considerable diversity in terms of size and number of introns and exons that encodes the N‐propeptide domain. Although the genomic structure of the human procollagen α1 (II) gene is quite different from the rat procollagen α1 (II) gene, the nucleotide coding sequences are 89% identical.

Original languageEnglish (US)
Pages (from-to)593-600
Number of pages8
JournalEuropean Journal of Biochemistry
Volume195
Issue number3
DOIs
StatePublished - Jan 1 1991

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Procollagen
Introns
Collagen
Genes
Exons
Nucleotides
Fibrillar Collagens
Gene encoding
Rats
Sequence Analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

HUANG, MC. C., SEYER, J. M., THOMPSON, J. P., SPINELLA, D. G., CHEAH, K. S. E., & Kang, A. (1991). Genomic organization of the human procollagen α1 (II) collagen gene. European Journal of Biochemistry, 195(3), 593-600. https://doi.org/10.1111/j.1432-1033.1991.tb15742.x

Genomic organization of the human procollagen α1 (II) collagen gene. / HUANG, Min‐Chi ‐C; SEYER, Jerome M.; THOMPSON, James P.; SPINELLA, Dominic G.; CHEAH, Kathy S.E.; Kang, Andrew.

In: European Journal of Biochemistry, Vol. 195, No. 3, 01.01.1991, p. 593-600.

Research output: Contribution to journalArticle

HUANG, Min‐Chi ‐C ; SEYER, Jerome M. ; THOMPSON, James P. ; SPINELLA, Dominic G. ; CHEAH, Kathy S.E. ; Kang, Andrew. / Genomic organization of the human procollagen α1 (II) collagen gene. In: European Journal of Biochemistry. 1991 ; Vol. 195, No. 3. pp. 593-600.
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