Genotype and severity of long QT syndrome

Jeffrey Towbin, Z. Wang, H. Li

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Sudden cardiac death occurs in the United States with an incidence greater than 300,000 persons per year. The underlying cause of death is commonly considered to be due to primary or secondary arrhythmias. In cases in which no structural heart disease can be identified, the long QT syndromes (LQTS) are now commonly considered as likely causes. Multiple genes causing LQTS have been identified thus far, all encoding cardiac ion channels. These include two potassium channel α-subunits (KVLQT1, HERG), two potassium channel β-subunits (minK, MiRP1), and one sodium channel gene (SCN5A). The purpose of this review is to describe the current understanding of the molecular genetics of LQTS and the resultant phenotypes.

Original languageEnglish (US)
Pages (from-to)574-579
Number of pages6
JournalDrug Metabolism and Disposition
Volume29
Issue number4 II
StatePublished - Apr 18 2001
Externally publishedYes

Fingerprint

Long QT Syndrome
Potassium Channels
Genotype
Mink
Sodium Channels
Sudden Cardiac Death
Ion Channels
Genes
Cardiac Arrhythmias
Molecular Biology
Cause of Death
Heart Diseases
Phenotype
Incidence

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Genotype and severity of long QT syndrome. / Towbin, Jeffrey; Wang, Z.; Li, H.

In: Drug Metabolism and Disposition, Vol. 29, No. 4 II, 18.04.2001, p. 574-579.

Research output: Contribution to journalArticle

Towbin, J, Wang, Z & Li, H 2001, 'Genotype and severity of long QT syndrome', Drug Metabolism and Disposition, vol. 29, no. 4 II, pp. 574-579.
Towbin, Jeffrey ; Wang, Z. ; Li, H. / Genotype and severity of long QT syndrome. In: Drug Metabolism and Disposition. 2001 ; Vol. 29, No. 4 II. pp. 574-579.
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