Gestational Nicotine Exposure Attenuates Nicotine-Stimulated Dopamine Release in the Nucleus Accumbens Shell of Adolescent Lewis Rats

Victoria B. Kane, Yitong Fu, Shannon G. Matta, Burt Sharp

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Abstract

The effects of chronic gestational exposure to nicotine on the nucleus accumbens dopamine response to acute nicotine were determined during adolescence (postnatal day 29-36) in cross-fostered and noncross-fostered Lewis rats. In both males and females, gestational nicotine exposure diminished the adolescent nucleus accumbens dopamine response to 0.07 mg/kg nicotine i.v. (p < 0.05). However, dopamine responses to 0.105 mg/kg nicotine were unaffected by gestational nicotine treatment and were similar in both genders. Furthermore, in both female and male gestational nicotine and control groups, the dopamine response to nicotine (0.105) was the same as that observed to the lower dose of nicotine in gestational controls. Thus, in adolescent male and female Lewis rats, gestational nicotine exposure attenuated nucleus accumbens dopamine release to a maximally stimulative dose of nicotine. Unexpectedly, in female gestational controls cross-fostering per se reduced nucleus accumbens dopamine secretion to 0.07 mg/kg nicotine (p < 0.05). These investigations suggest that gestational nicotine exposure could modify the acute reinforcing effects of nicotine in adolescent rats, whereas early postnatal stressors, (e.g., cross-fostering) may affect nicotine-induced reinforcement in female but not male adolescents.

Original languageEnglish (US)
Pages (from-to)521-528
Number of pages8
JournalJournal of Pharmacology and Experimental Therapeutics
Volume308
Issue number2
DOIs
StatePublished - Feb 1 2004

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Nucleus Accumbens
Nicotine
Dopamine
Foster Home Care

All Science Journal Classification (ASJC) codes

  • Pharmacology

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Gestational Nicotine Exposure Attenuates Nicotine-Stimulated Dopamine Release in the Nucleus Accumbens Shell of Adolescent Lewis Rats. / Kane, Victoria B.; Fu, Yitong; Matta, Shannon G.; Sharp, Burt.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 308, No. 2, 01.02.2004, p. 521-528.

Research output: Contribution to journalArticle

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