Gestational vitamin 25(OH)D status as a risk factor for receptive language development

A 24-month, longitudinal, observational study

Frances Tylavsky, Mehmet Kocak, Laura Murphy, Joyce Graff, Frederick B. Palmer, Eszter Völgyi, Alicia Diaz Thomas, Robert J. Ferry

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Emerging data suggest that vitamin D status during childhood and adolescence can affect neurocognitive development. The purpose of this study was to investigate whether gestational 25(OH)D status is associated with early childhood cognitive and receptive language development. The Conditions Affecting Neurocognitive Development and Learning in Early Childhood Study (CANDLE) study enrolled 1503 mother-child dyads during the second trimester of healthy singleton pregnancies from Shelby County TN. Among 1020 participants of the total CANDLE cohort for whom 25(OH)D levels were available, mean gestational 25(OH)D level during the second trimester was 22.3 ng/mL (range 5.9–68.4), with 41.7% of values <20 ng/dL. Cognitive and language scaled scores increased in a stair-step manner as gestational 25(OH)D levels in the second trimester rose from <20 ng/dL, through 20–29.99 ng/dL, to ≥30 ng/dL. When controlling for socioeconomic status, race, use of tobacco products, gestational age of the child at birth, and age at the 2-year assessment, the gestational 25(OH)D was positively related to receptive language development (p < 0.017), but not cognitive or expressive language.

Original languageEnglish (US)
Pages (from-to)9918-9930
Number of pages13
JournalNutrients
Volume7
Issue number12
DOIs
StatePublished - Dec 2 2015

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language development
Language Development
Second Pregnancy Trimester
observational studies
childhood
Vitamins
Observational Studies
Longitudinal Studies
vitamins
risk factors
Language
Learning
learning
adolescence
tobacco use
Social Class
Vitamin D
Tobacco Products
Gestational Age
gestational age

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Gestational vitamin 25(OH)D status as a risk factor for receptive language development : A 24-month, longitudinal, observational study. / Tylavsky, Frances; Kocak, Mehmet; Murphy, Laura; Graff, Joyce; Palmer, Frederick B.; Völgyi, Eszter; Diaz Thomas, Alicia; Ferry, Robert J.

In: Nutrients, Vol. 7, No. 12, 02.12.2015, p. 9918-9930.

Research output: Contribution to journalArticle

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