Giant-sized condyloma of the breast with focal acantholytic changes

Paul Googe, Sung J. Chung, John Simmons, Roy King

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: A healthy 26-year-old pregnant woman presented with a 6.0-cm exophytic mass in her left inframammary fold. The lesion was surgically excised. Methods: Histopathologic sections of the skin lesion were reviewed in hematoxylin and eosin-stained slides. Additional sections were studied by an in situ hybridization method for human papillomavirus DNA (HPV) types 6 and 11. Results: The histopathologic examination demonstrated a benign exophytic, verrucous and papillary epidermal proliferation with features of condyloma acuminatum. Reactivity to HPV DNA types 6 and 11 was demonstrated by in situ hybridization method. The epidermis adjacent to, and focally within, the neoplasm showed multiple areas of suprabasilar and intraepidermal acantholysis without dyskeratosis. Conclusions: Condylomas related to HPV 6 and 11 may be found in extragenital locations including conjunctiva, oral and nasal mucosa. To our knowledge, however, the extragenital condylomas described in the literature have not included the giant-sized variant. We describe an example of a benign, giant-sized condyloma acuminatum of the breast with nearby acantholytic alterations similar to Hailey-Hailey disease. (C) Munksgaard 2000.

Original languageEnglish (US)
Pages (from-to)319-322
Number of pages4
JournalJournal of Cutaneous Pathology
Volume27
Issue number6
DOIs
StatePublished - Jun 30 2000

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Breast
Human papillomavirus 11
Human papillomavirus 6
DNA
In Situ Hybridization
Buschke-Lowenstein Tumor
Benign Familial Pemphigus
Acantholysis
Condylomata Acuminata
Nasal Mucosa
Conjunctiva
Mouth Mucosa
Hematoxylin
Eosine Yellowish-(YS)
Epidermis
Pregnant Women
Skin
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Cite this

Giant-sized condyloma of the breast with focal acantholytic changes. / Googe, Paul; Chung, Sung J.; Simmons, John; King, Roy.

In: Journal of Cutaneous Pathology, Vol. 27, No. 6, 30.06.2000, p. 319-322.

Research output: Contribution to journalArticle

Googe, Paul ; Chung, Sung J. ; Simmons, John ; King, Roy. / Giant-sized condyloma of the breast with focal acantholytic changes. In: Journal of Cutaneous Pathology. 2000 ; Vol. 27, No. 6. pp. 319-322.
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