Glomerulocystic kidney disease

John Bissler, Brian J. Siroky, Hong Yin

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Glomerulocystic disease is a rare renal cystic disease with a long descriptive history. Findings from recent studies have significantly advanced the pathophysiological understanding of the disease processes leading to this peculiar phenotype. Many genetic syndromes associated with glomerulocystic disease have had their respective proteins localized to primary cilia or centrosomes. Transcriptional control of renal developmental pathways is dysregulated in obstructive diseases that also lead to glomerulocystic disease, emphasizing the importance of transcriptional choreography between renal development and renal cystic disease.

Original languageEnglish (US)
Pages (from-to)2049-2059
Number of pages11
JournalPediatric Nephrology
Volume25
Issue number10
DOIs
StatePublished - Oct 1 2010
Externally publishedYes

Fingerprint

Kidney Diseases
Cystic Kidney Diseases
Kidney
Centrosome
Cilia
History
Phenotype
Proteins

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Glomerulocystic kidney disease. / Bissler, John; Siroky, Brian J.; Yin, Hong.

In: Pediatric Nephrology, Vol. 25, No. 10, 01.10.2010, p. 2049-2059.

Research output: Contribution to journalReview article

Bissler, John ; Siroky, Brian J. ; Yin, Hong. / Glomerulocystic kidney disease. In: Pediatric Nephrology. 2010 ; Vol. 25, No. 10. pp. 2049-2059.
@article{7572ca77221a468db4349bb50912de37,
title = "Glomerulocystic kidney disease",
abstract = "Glomerulocystic disease is a rare renal cystic disease with a long descriptive history. Findings from recent studies have significantly advanced the pathophysiological understanding of the disease processes leading to this peculiar phenotype. Many genetic syndromes associated with glomerulocystic disease have had their respective proteins localized to primary cilia or centrosomes. Transcriptional control of renal developmental pathways is dysregulated in obstructive diseases that also lead to glomerulocystic disease, emphasizing the importance of transcriptional choreography between renal development and renal cystic disease.",
author = "John Bissler and Siroky, {Brian J.} and Hong Yin",
year = "2010",
month = "10",
day = "1",
doi = "10.1007/s00467-009-1416-2",
language = "English (US)",
volume = "25",
pages = "2049--2059",
journal = "Pediatric Nephrology",
issn = "0931-041X",
publisher = "Springer Verlag",
number = "10",

}

TY - JOUR

T1 - Glomerulocystic kidney disease

AU - Bissler, John

AU - Siroky, Brian J.

AU - Yin, Hong

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Glomerulocystic disease is a rare renal cystic disease with a long descriptive history. Findings from recent studies have significantly advanced the pathophysiological understanding of the disease processes leading to this peculiar phenotype. Many genetic syndromes associated with glomerulocystic disease have had their respective proteins localized to primary cilia or centrosomes. Transcriptional control of renal developmental pathways is dysregulated in obstructive diseases that also lead to glomerulocystic disease, emphasizing the importance of transcriptional choreography between renal development and renal cystic disease.

AB - Glomerulocystic disease is a rare renal cystic disease with a long descriptive history. Findings from recent studies have significantly advanced the pathophysiological understanding of the disease processes leading to this peculiar phenotype. Many genetic syndromes associated with glomerulocystic disease have had their respective proteins localized to primary cilia or centrosomes. Transcriptional control of renal developmental pathways is dysregulated in obstructive diseases that also lead to glomerulocystic disease, emphasizing the importance of transcriptional choreography between renal development and renal cystic disease.

UR - http://www.scopus.com/inward/record.url?scp=77956225837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956225837&partnerID=8YFLogxK

U2 - 10.1007/s00467-009-1416-2

DO - 10.1007/s00467-009-1416-2

M3 - Review article

VL - 25

SP - 2049

EP - 2059

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

IS - 10

ER -