Glutamate and synaptic plasticity at mammalian primary olfactory synapses

Matthew Ennis, Christiane Linster, Vassiliki Aroniadou-Anderjaska, Kelly Ciombor, Michael T. Shipley

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Glutamate is the transmitter at synapses from the olfactory nerve (ON) to mitral (Mi)/tufted cells, but very little is known about the functional properties of this synapse. This report summarizes in vitro physiological and computational modeling studies investigating glutamatergic neurotransmission at ON → Mi cell synapses. Single ON shocks in rat main olfactory bulb (MOB) slices elicit distinct early and late spiking components triggered, respectively, by (RS)-α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)/kainic acid (KA) and N-methyl-D-aspartate (NMDA) receptor activation. Modeling simulations showed that the placement of both AMPA/KA and NMDA receptors on Mi apical dendrites replicates the experimentally observed early and late Mi spiking responses to ON shocks. Brief, tetanic ON stimulation in vitro induced robust, selective long-term potentiation (LTP) of NMDA receptor-dependent spiking. Modeling experiments disclosed several potential mechanisms underlying the selective LTP of NMDA receptor-dependent spiking. These findings demonstrate that ON → Mi cell transmission exhibits a novel form of plasticity whereby high frequency synaptic activity induces selective LTP of NMDA receptor-dependent spiking.

Original languageEnglish (US)
Pages (from-to)457-466
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume855
DOIs
StatePublished - Jan 1 1998

Fingerprint

Olfactory Nerve
Neuronal Plasticity
N-Methyl-D-Aspartate Receptors
Synapses
Plasticity
Glutamic Acid
Long-Term Potentiation
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Kainic Acid
Neurons
Shock
Isoxazoles
Olfactory Bulb
Rats
Dendrites
Transmitters
Synaptic Transmission
Chemical activation
Nerve
Computer simulation

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Glutamate and synaptic plasticity at mammalian primary olfactory synapses. / Ennis, Matthew; Linster, Christiane; Aroniadou-Anderjaska, Vassiliki; Ciombor, Kelly; Shipley, Michael T.

In: Annals of the New York Academy of Sciences, Vol. 855, 01.01.1998, p. 457-466.

Research output: Contribution to journalArticle

Ennis, Matthew ; Linster, Christiane ; Aroniadou-Anderjaska, Vassiliki ; Ciombor, Kelly ; Shipley, Michael T. / Glutamate and synaptic plasticity at mammalian primary olfactory synapses. In: Annals of the New York Academy of Sciences. 1998 ; Vol. 855. pp. 457-466.
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