Glutamate decarboxylase immunoreactive neurons in rat neostriatum

their morphological types and populations

Hitoshi Kita, S. T. Kitai

Research output: Contribution to journalArticle

299 Citations (Scopus)

Abstract

Morphological types and populations of glutamate decarboxylase (GAD)-immunoreactive neurons in rat neostriatum (Str) were studied. Str of colchicine-treated animals contained 3 types of neurons immunoreactive for GAD. The first type, which makes up 80-84% of Str neurons, was medium in size and showed moderate intensity GAD-staining. The somatic morphology of the neurons was identical to the medium-spiny projection neuron. The second type, 3-5% of Str neurons, was small to medium in size and was in-intensely stained for GAD. The somata of the neurons were round or oval and contained a narrow ring of cytoplasm surrounding the nucleus, which often had nuclear invaginations. There were only a few in each section of the third type, which were large, polygonal, and intensely stained. GAD-immunoreactive neurons, including all 3 types, ranged from 85-87% of the total neuron population. The present study indicated that GABAergic neurons in the Str are not a single morphological type and that most Str projection neurons are GABAergic.

Original languageEnglish (US)
Pages (from-to)346-352
Number of pages7
JournalBrain Research
Volume447
Issue number2
DOIs
StatePublished - May 3 1988

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Neostriatum
Glutamate Decarboxylase
Neurons
Population
GABAergic Neurons
Colchicine
Carisoprodol
Cytoplasm
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Glutamate decarboxylase immunoreactive neurons in rat neostriatum : their morphological types and populations. / Kita, Hitoshi; Kitai, S. T.

In: Brain Research, Vol. 447, No. 2, 03.05.1988, p. 346-352.

Research output: Contribution to journalArticle

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