Glycemia management in acute ischemic stroke

current concepts and novel therapeutic targets

Lina Palaiodimou, Vasileios Arsenios Lioutas, Vaia Lambadiari, George P. Paraskevas, Konstantinos Voumvourakis, Georgios Tsivgoulis

Research output: Contribution to journalReview article

Abstract

Hyperglycemia on hospital admission is a common phenomenon in acute ischemic stroke patients and represents an independent predictor of poor clinical outcome with or without acute recanalization therapies (systemic thrombolysis or mechanical thrombectomy). Effective restoration of normoglycemia is considered to be beneficial, but conclusive evidence from randomized controlled clinical trials and specific recommendations are lacking. In addition, aggressive glucose control can be complicated by hypoglycemia leading to early neurological deterioration. We conducted a systematic literature review with the aim of addressing several questions: timing of glucose control, target range, type of insulin delivery, duration and practicability of glucose-lowering protocols. Special issues regarding mechanical thrombectomy and glycemic variability can then be investigated in future trials which are also being considered.

Original languageEnglish (US)
JournalPostgraduate medicine
DOIs
StateAccepted/In press - Jan 1 2019

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Thrombectomy
Stroke
Glucose
Mechanical Thrombolysis
Hypoglycemia
Hyperglycemia
Therapeutics
Randomized Controlled Trials
Insulin

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Glycemia management in acute ischemic stroke : current concepts and novel therapeutic targets. / Palaiodimou, Lina; Lioutas, Vasileios Arsenios; Lambadiari, Vaia; Paraskevas, George P.; Voumvourakis, Konstantinos; Tsivgoulis, Georgios.

In: Postgraduate medicine, 01.01.2019.

Research output: Contribution to journalReview article

Palaiodimou, Lina ; Lioutas, Vasileios Arsenios ; Lambadiari, Vaia ; Paraskevas, George P. ; Voumvourakis, Konstantinos ; Tsivgoulis, Georgios. / Glycemia management in acute ischemic stroke : current concepts and novel therapeutic targets. In: Postgraduate medicine. 2019.
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