Livelli glicemici «soglia» e aborto spontaneo nel I trimestre nelle gestanti affette da diabete mellito insulino-dipendente

Translated title of the contribution: Glycemic thresholds for spontaneous abortion during the first trimester in insulin-dependent diabetic pregnant women

G. Mello, E. Parretti, F. Mecacci, P. La Torre, R. Lucchetti, R. Cioni, Laura Detti, G. Scarselli

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background and aim. To evaluate the hypothesis that insulin-dependent diabetic (IDDM) pregnant women have a threshold of glycemic control during the first trimester of prenancy for an increased risk of spontaneous abortion. Materials and methods. Seventy IDDM pregnant women were enrolled before the 9th week of gestation and monitored throughout pregnancy. Fifteen pregnancies (21.4%) led to spontaneous abortion within the first trimester (study group) and 55 (76%) continued until term (control group). In order to evaluate the differences between the study group and the control group variance analysis and Student's t-test were used for constant variables and X2 and Fisher's exact test for discrete variables; p<0.05 was considered statistically significance. Results. Mean levels of glycosylated hemoglobin (HbAIc) and fructosamine at the initial prenatal visit were significantly higher in the study group (p<0.03) compared to the control group. The threshold for an increased risk of spontaneous abortion in the first trimester was found to be initial concentrations >8% for HbAIc and >300 mmol/l for fructosamine. Conclusions. Pregnant women suffering from IDDM with initial HbAIc levels higher than 8% and fructosamine >3 mmol/l have an increased risk of spontaneous abortion in the first trimester of pregnancy. Below this threshold the risk of spontaneous abortion during the first trimester of pregnancy is similar to that for non-diabetic pregnant women.

Original languageItalian
Pages (from-to)365-370
Number of pages6
JournalMinerva Ginecologica
Volume49
Issue number9
StatePublished - Sep 1 1997
Externally publishedYes

Fingerprint

Spontaneous Abortion
First Pregnancy Trimester
Pregnant Women
Type 1 Diabetes Mellitus
Insulin
Fructosamine
Pregnancy
Control Groups
Analysis of Variance
Students

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Mello, G., Parretti, E., Mecacci, F., La Torre, P., Lucchetti, R., Cioni, R., ... Scarselli, G. (1997). Livelli glicemici «soglia» e aborto spontaneo nel I trimestre nelle gestanti affette da diabete mellito insulino-dipendente. Minerva Ginecologica, 49(9), 365-370.

Livelli glicemici «soglia» e aborto spontaneo nel I trimestre nelle gestanti affette da diabete mellito insulino-dipendente. / Mello, G.; Parretti, E.; Mecacci, F.; La Torre, P.; Lucchetti, R.; Cioni, R.; Detti, Laura; Scarselli, G.

In: Minerva Ginecologica, Vol. 49, No. 9, 01.09.1997, p. 365-370.

Research output: Contribution to journalArticle

Mello, G, Parretti, E, Mecacci, F, La Torre, P, Lucchetti, R, Cioni, R, Detti, L & Scarselli, G 1997, 'Livelli glicemici «soglia» e aborto spontaneo nel I trimestre nelle gestanti affette da diabete mellito insulino-dipendente', Minerva Ginecologica, vol. 49, no. 9, pp. 365-370.
Mello G, Parretti E, Mecacci F, La Torre P, Lucchetti R, Cioni R et al. Livelli glicemici «soglia» e aborto spontaneo nel I trimestre nelle gestanti affette da diabete mellito insulino-dipendente. Minerva Ginecologica. 1997 Sep 1;49(9):365-370.
Mello, G. ; Parretti, E. ; Mecacci, F. ; La Torre, P. ; Lucchetti, R. ; Cioni, R. ; Detti, Laura ; Scarselli, G. / Livelli glicemici «soglia» e aborto spontaneo nel I trimestre nelle gestanti affette da diabete mellito insulino-dipendente. In: Minerva Ginecologica. 1997 ; Vol. 49, No. 9. pp. 365-370.
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abstract = "Background and aim. To evaluate the hypothesis that insulin-dependent diabetic (IDDM) pregnant women have a threshold of glycemic control during the first trimester of prenancy for an increased risk of spontaneous abortion. Materials and methods. Seventy IDDM pregnant women were enrolled before the 9th week of gestation and monitored throughout pregnancy. Fifteen pregnancies (21.4{\%}) led to spontaneous abortion within the first trimester (study group) and 55 (76{\%}) continued until term (control group). In order to evaluate the differences between the study group and the control group variance analysis and Student's t-test were used for constant variables and X2 and Fisher's exact test for discrete variables; p<0.05 was considered statistically significance. Results. Mean levels of glycosylated hemoglobin (HbAIc) and fructosamine at the initial prenatal visit were significantly higher in the study group (p<0.03) compared to the control group. The threshold for an increased risk of spontaneous abortion in the first trimester was found to be initial concentrations >8{\%} for HbAIc and >300 mmol/l for fructosamine. Conclusions. Pregnant women suffering from IDDM with initial HbAIc levels higher than 8{\%} and fructosamine >3 mmol/l have an increased risk of spontaneous abortion in the first trimester of pregnancy. Below this threshold the risk of spontaneous abortion during the first trimester of pregnancy is similar to that for non-diabetic pregnant women.",
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