Glycerin Suppositories Use in Very Low Birth Weight Infants

Shalinkumar Patel, Narendra Dereddy, Ajay Talati, Kan Gaston, Ramasubbareddy Dhanireddy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective To study the characteristics of very low birth weight (VLBW) infants receiving glycerin suppositories (GS) and evaluate the association of GS use with outcomes. Study Design This is a retrospective study of VLBW infants admitted to a level III neonatal intensive care unit. Infants with birth weight between 500 and 1,499 g were evaluated. We evaluated the frequency of GS use and compared the characteristics and outcomes of the GS group with the no-GS group. Multivariate analyses controlling for gestational age and small for gestational age status were performed to study the effect of GS on outcomes. Results A total of 1,073 infants were included in the study. Out of those, 527 (49.1%) infants received GS. Incidence of necrotizing enterocolitis was not significantly different between the two groups, while days to reach full enteral feeds and length of hospital stay were significantly longer in the GS group. Conclusion Frequent use of GS warrants further prospective studies to evaluate its safety and efficacy in view of our study showing association with longer time to reach full enteral feeds. We speculate that GS use could be a marker for gastrointestinal dysmotility and hence the association with unfavorable clinical outcomes.

Original languageEnglish (US)
Pages (from-to)169-173
Number of pages5
JournalAmerican Journal of Perinatology
Volume34
Issue number2
DOIs
StatePublished - Jan 1 2017

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Suppositories
Very Low Birth Weight Infant
Glycerol
Gestational Age
Small Intestine
Length of Stay
Necrotizing Enterocolitis
Neonatal Intensive Care Units
Birth Weight
Multivariate Analysis
Retrospective Studies
Prospective Studies
Safety

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Glycerin Suppositories Use in Very Low Birth Weight Infants. / Patel, Shalinkumar; Dereddy, Narendra; Talati, Ajay; Gaston, Kan; Dhanireddy, Ramasubbareddy.

In: American Journal of Perinatology, Vol. 34, No. 2, 01.01.2017, p. 169-173.

Research output: Contribution to journalArticle

Patel, Shalinkumar ; Dereddy, Narendra ; Talati, Ajay ; Gaston, Kan ; Dhanireddy, Ramasubbareddy. / Glycerin Suppositories Use in Very Low Birth Weight Infants. In: American Journal of Perinatology. 2017 ; Vol. 34, No. 2. pp. 169-173.
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