Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects

Richard J. Bloomer, Lesley C. Tschume, Webb Smith

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: To determine the efficacy of glycine propionyl-L-carnitine (GPLC) to decrease lipid peroxidation, elevate nitric oxide, and improve blood lipid profiles in human subjects. Methods: Thirty untrained, normolipidemic subjects performed eight weeks of supervised aerobic exercise while supplementing GPLC at one of two doses (1 or 3 grams daily of PLC + glycine) or placebo, following random assignment in a double-blind manner. Fasting blood samples were analyzed at rest for malondialdehyde, nitric oxide, and lipids before and after the intervention. Results: Malondialdehyde was decreased (p<0.05) from pre- to post-intervention with 1 g GPLC (1.08±0.24 vs. 0.69±0.25 μmol·L -1) and 3 g GPLC(0.94±0.18 vs. 0.66±0.17 μmol·L -1), but did not change statistically (p>0.05) with placebo (1.12±0.21 vs. 1.03±0.23 μmol·L -1). Nitric oxide was increased (p<0.05) from pre- to post-intervention with 3 g GPLC (21.34±2.27 vs. 29.46±3.61 μmol·L -1), but did not change statistically (p>0.05) with 1 g GPLC (23.22±4.13 vs. 26.24±4.32 μmol·L -1) or placebo (24.31±3.90 vs. 26.14±4.11 μmol·L -1). No main effects or interaction effects were noted for blood lipids (p>0.05). Conclusion: GPLC supplementation combinedwith eight weeks of aerobic exercise decreases lipid peroxidation and elevates nitric oxide, but does not further improve blood lipid profiles in normolipidemic subjects.

Original languageEnglish (US)
Pages (from-to)131-141
Number of pages11
JournalInternational Journal for Vitamin and Nutrition Research
Volume79
Issue number3
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Carnitine
Lipid Peroxidation
Nitric Oxide
Lipids
Placebos
Malondialdehyde
Exercise
Glycine
Fasting
glycine propionyl carnitine

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects. / Bloomer, Richard J.; Tschume, Lesley C.; Smith, Webb.

In: International Journal for Vitamin and Nutrition Research, Vol. 79, No. 3, 2009, p. 131-141.

Research output: Contribution to journalArticle

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abstract = "Objective: To determine the efficacy of glycine propionyl-L-carnitine (GPLC) to decrease lipid peroxidation, elevate nitric oxide, and improve blood lipid profiles in human subjects. Methods: Thirty untrained, normolipidemic subjects performed eight weeks of supervised aerobic exercise while supplementing GPLC at one of two doses (1 or 3 grams daily of PLC + glycine) or placebo, following random assignment in a double-blind manner. Fasting blood samples were analyzed at rest for malondialdehyde, nitric oxide, and lipids before and after the intervention. Results: Malondialdehyde was decreased (p<0.05) from pre- to post-intervention with 1 g GPLC (1.08±0.24 vs. 0.69±0.25 μmol·L -1) and 3 g GPLC(0.94±0.18 vs. 0.66±0.17 μmol·L -1), but did not change statistically (p>0.05) with placebo (1.12±0.21 vs. 1.03±0.23 μmol·L -1). Nitric oxide was increased (p<0.05) from pre- to post-intervention with 3 g GPLC (21.34±2.27 vs. 29.46±3.61 μmol·L -1), but did not change statistically (p>0.05) with 1 g GPLC (23.22±4.13 vs. 26.24±4.32 μmol·L -1) or placebo (24.31±3.90 vs. 26.14±4.11 μmol·L -1). No main effects or interaction effects were noted for blood lipids (p>0.05). Conclusion: GPLC supplementation combinedwith eight weeks of aerobic exercise decreases lipid peroxidation and elevates nitric oxide, but does not further improve blood lipid profiles in normolipidemic subjects.",
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N2 - Objective: To determine the efficacy of glycine propionyl-L-carnitine (GPLC) to decrease lipid peroxidation, elevate nitric oxide, and improve blood lipid profiles in human subjects. Methods: Thirty untrained, normolipidemic subjects performed eight weeks of supervised aerobic exercise while supplementing GPLC at one of two doses (1 or 3 grams daily of PLC + glycine) or placebo, following random assignment in a double-blind manner. Fasting blood samples were analyzed at rest for malondialdehyde, nitric oxide, and lipids before and after the intervention. Results: Malondialdehyde was decreased (p<0.05) from pre- to post-intervention with 1 g GPLC (1.08±0.24 vs. 0.69±0.25 μmol·L -1) and 3 g GPLC(0.94±0.18 vs. 0.66±0.17 μmol·L -1), but did not change statistically (p>0.05) with placebo (1.12±0.21 vs. 1.03±0.23 μmol·L -1). Nitric oxide was increased (p<0.05) from pre- to post-intervention with 3 g GPLC (21.34±2.27 vs. 29.46±3.61 μmol·L -1), but did not change statistically (p>0.05) with 1 g GPLC (23.22±4.13 vs. 26.24±4.32 μmol·L -1) or placebo (24.31±3.90 vs. 26.14±4.11 μmol·L -1). No main effects or interaction effects were noted for blood lipids (p>0.05). Conclusion: GPLC supplementation combinedwith eight weeks of aerobic exercise decreases lipid peroxidation and elevates nitric oxide, but does not further improve blood lipid profiles in normolipidemic subjects.

AB - Objective: To determine the efficacy of glycine propionyl-L-carnitine (GPLC) to decrease lipid peroxidation, elevate nitric oxide, and improve blood lipid profiles in human subjects. Methods: Thirty untrained, normolipidemic subjects performed eight weeks of supervised aerobic exercise while supplementing GPLC at one of two doses (1 or 3 grams daily of PLC + glycine) or placebo, following random assignment in a double-blind manner. Fasting blood samples were analyzed at rest for malondialdehyde, nitric oxide, and lipids before and after the intervention. Results: Malondialdehyde was decreased (p<0.05) from pre- to post-intervention with 1 g GPLC (1.08±0.24 vs. 0.69±0.25 μmol·L -1) and 3 g GPLC(0.94±0.18 vs. 0.66±0.17 μmol·L -1), but did not change statistically (p>0.05) with placebo (1.12±0.21 vs. 1.03±0.23 μmol·L -1). Nitric oxide was increased (p<0.05) from pre- to post-intervention with 3 g GPLC (21.34±2.27 vs. 29.46±3.61 μmol·L -1), but did not change statistically (p>0.05) with 1 g GPLC (23.22±4.13 vs. 26.24±4.32 μmol·L -1) or placebo (24.31±3.90 vs. 26.14±4.11 μmol·L -1). No main effects or interaction effects were noted for blood lipids (p>0.05). Conclusion: GPLC supplementation combinedwith eight weeks of aerobic exercise decreases lipid peroxidation and elevates nitric oxide, but does not further improve blood lipid profiles in normolipidemic subjects.

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JF - Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie

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