Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy

Mark F. McLaughlin, Jonathan Woodward, Rose A. Boll, Jonathan Wall, Adam J. Rondinone, Stephen Kennel, Saed Mirzadeh, J. David Robertson

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Targeted radiotherapies maximize cytotoxicty to cancer cells. In vivo α-generator targeted radiotherapies can deliver multiple α particles to a receptor site dramatically amplifying the radiation dose delivered to the target. The major challenge with α-generator radiotherapies is that traditional chelating moieties are unable to sequester the radioactive daughters in the bioconjugate which is critical to minimize toxicity to healthy, non-target tissue. The recoil energy of the 225Ac daughters following α decay will sever any metal-ligand bond used to form the bioconjugate. This work demonstrates that an engineered multilayered nanoparticle-antibody conjugate can deliver multiple α radiations and contain the decay daughters of 225Ac while targeting biologically relevant receptors in a female BALB/c mouse model. These multi-shell nanoparticles combine the radiation resistance of lanthanide phosphate to contain 225Ac and its radioactive decay daughters, the magnetic properties of gadolinium phosphate for easy separation, and established gold chemistry for attachment of targeting moieties.

Original languageEnglish (US)
Article numbere54531
JournalPloS one
Volume8
Issue number1
DOIs
StatePublished - Jan 18 2013

Fingerprint

rare earth elements
Radiotherapy
radiotherapy
nanoparticles
Gold
Nanoparticles
gold
deterioration
phosphates
Radiation
magnetic properties
gadolinium
radiation resistance
receptors
Gadolinium
Chelation
Dosimetry
Toxicity
Magnetic properties
chemistry

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

McLaughlin, M. F., Woodward, J., Boll, R. A., Wall, J., Rondinone, A. J., Kennel, S., ... Robertson, J. D. (2013). Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy. PloS one, 8(1), [e54531]. https://doi.org/10.1371/journal.pone.0054531

Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy. / McLaughlin, Mark F.; Woodward, Jonathan; Boll, Rose A.; Wall, Jonathan; Rondinone, Adam J.; Kennel, Stephen; Mirzadeh, Saed; Robertson, J. David.

In: PloS one, Vol. 8, No. 1, e54531, 18.01.2013.

Research output: Contribution to journalArticle

McLaughlin, MF, Woodward, J, Boll, RA, Wall, J, Rondinone, AJ, Kennel, S, Mirzadeh, S & Robertson, JD 2013, 'Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy', PloS one, vol. 8, no. 1, e54531. https://doi.org/10.1371/journal.pone.0054531
McLaughlin, Mark F. ; Woodward, Jonathan ; Boll, Rose A. ; Wall, Jonathan ; Rondinone, Adam J. ; Kennel, Stephen ; Mirzadeh, Saed ; Robertson, J. David. / Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy. In: PloS one. 2013 ; Vol. 8, No. 1.
@article{4bb549a5d0974cb886f49aaa26146a5f,
title = "Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy",
abstract = "Targeted radiotherapies maximize cytotoxicty to cancer cells. In vivo α-generator targeted radiotherapies can deliver multiple α particles to a receptor site dramatically amplifying the radiation dose delivered to the target. The major challenge with α-generator radiotherapies is that traditional chelating moieties are unable to sequester the radioactive daughters in the bioconjugate which is critical to minimize toxicity to healthy, non-target tissue. The recoil energy of the 225Ac daughters following α decay will sever any metal-ligand bond used to form the bioconjugate. This work demonstrates that an engineered multilayered nanoparticle-antibody conjugate can deliver multiple α radiations and contain the decay daughters of 225Ac while targeting biologically relevant receptors in a female BALB/c mouse model. These multi-shell nanoparticles combine the radiation resistance of lanthanide phosphate to contain 225Ac and its radioactive decay daughters, the magnetic properties of gadolinium phosphate for easy separation, and established gold chemistry for attachment of targeting moieties.",
author = "McLaughlin, {Mark F.} and Jonathan Woodward and Boll, {Rose A.} and Jonathan Wall and Rondinone, {Adam J.} and Stephen Kennel and Saed Mirzadeh and Robertson, {J. David}",
year = "2013",
month = "1",
day = "18",
doi = "10.1371/journal.pone.0054531",
language = "English (US)",
volume = "8",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",

}

TY - JOUR

T1 - Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy

AU - McLaughlin, Mark F.

AU - Woodward, Jonathan

AU - Boll, Rose A.

AU - Wall, Jonathan

AU - Rondinone, Adam J.

AU - Kennel, Stephen

AU - Mirzadeh, Saed

AU - Robertson, J. David

PY - 2013/1/18

Y1 - 2013/1/18

N2 - Targeted radiotherapies maximize cytotoxicty to cancer cells. In vivo α-generator targeted radiotherapies can deliver multiple α particles to a receptor site dramatically amplifying the radiation dose delivered to the target. The major challenge with α-generator radiotherapies is that traditional chelating moieties are unable to sequester the radioactive daughters in the bioconjugate which is critical to minimize toxicity to healthy, non-target tissue. The recoil energy of the 225Ac daughters following α decay will sever any metal-ligand bond used to form the bioconjugate. This work demonstrates that an engineered multilayered nanoparticle-antibody conjugate can deliver multiple α radiations and contain the decay daughters of 225Ac while targeting biologically relevant receptors in a female BALB/c mouse model. These multi-shell nanoparticles combine the radiation resistance of lanthanide phosphate to contain 225Ac and its radioactive decay daughters, the magnetic properties of gadolinium phosphate for easy separation, and established gold chemistry for attachment of targeting moieties.

AB - Targeted radiotherapies maximize cytotoxicty to cancer cells. In vivo α-generator targeted radiotherapies can deliver multiple α particles to a receptor site dramatically amplifying the radiation dose delivered to the target. The major challenge with α-generator radiotherapies is that traditional chelating moieties are unable to sequester the radioactive daughters in the bioconjugate which is critical to minimize toxicity to healthy, non-target tissue. The recoil energy of the 225Ac daughters following α decay will sever any metal-ligand bond used to form the bioconjugate. This work demonstrates that an engineered multilayered nanoparticle-antibody conjugate can deliver multiple α radiations and contain the decay daughters of 225Ac while targeting biologically relevant receptors in a female BALB/c mouse model. These multi-shell nanoparticles combine the radiation resistance of lanthanide phosphate to contain 225Ac and its radioactive decay daughters, the magnetic properties of gadolinium phosphate for easy separation, and established gold chemistry for attachment of targeting moieties.

UR - http://www.scopus.com/inward/record.url?scp=84872565992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872565992&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0054531

DO - 10.1371/journal.pone.0054531

M3 - Article

VL - 8

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 1

M1 - e54531

ER -