Granular cell astrocytoma of the cerebellum: Report of the first case

Ali Saad, Jun Mo, Lili Miles, David Witte

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Granular cell astrocytomas are an uncommon morphologic variant of infiltrating gliomas characterized by relatively large tumor cells with granular cytoplasm occupying variable proportions of the tumor. These tumors are thought to be more aggressive than similar tumors with no granular cell component. The tumor occurred in a 9-year-old girl who was immunocompromised owing to liver transplantation. Histologically, the tumor corresponded to World Health Organization grade II. It extensively infiltrated the cerebellum and was composed, predominantly, of large cells with eosinophilic granular cytoplasm. These cells coexpressed glial fibrillary acidic protein and CD68. Of the 49 cases of granular cell astrocytomas reported to date, none have involved the cerebellum. To our knowledge, the tumor described herein represents the first case of cerebellar granular cell astrocytoma. Pathologic features and diagnostic pitfalls are explored.

Original languageEnglish (US)
Pages (from-to)602-607
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume126
Issue number4
DOIs
StatePublished - Oct 1 2006

Fingerprint

Astrocytoma
Cerebellum
Neoplasms
Cytoplasm
Granular Cell Tumor
Glial Fibrillary Acidic Protein
Cellular Structures
Glioma
Liver Transplantation

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Granular cell astrocytoma of the cerebellum : Report of the first case. / Saad, Ali; Mo, Jun; Miles, Lili; Witte, David.

In: American Journal of Clinical Pathology, Vol. 126, No. 4, 01.10.2006, p. 602-607.

Research output: Contribution to journalArticle

Saad, Ali ; Mo, Jun ; Miles, Lili ; Witte, David. / Granular cell astrocytoma of the cerebellum : Report of the first case. In: American Journal of Clinical Pathology. 2006 ; Vol. 126, No. 4. pp. 602-607.
@article{9b62c861490d4bc9a7cd3190490ffc96,
title = "Granular cell astrocytoma of the cerebellum: Report of the first case",
abstract = "Granular cell astrocytomas are an uncommon morphologic variant of infiltrating gliomas characterized by relatively large tumor cells with granular cytoplasm occupying variable proportions of the tumor. These tumors are thought to be more aggressive than similar tumors with no granular cell component. The tumor occurred in a 9-year-old girl who was immunocompromised owing to liver transplantation. Histologically, the tumor corresponded to World Health Organization grade II. It extensively infiltrated the cerebellum and was composed, predominantly, of large cells with eosinophilic granular cytoplasm. These cells coexpressed glial fibrillary acidic protein and CD68. Of the 49 cases of granular cell astrocytomas reported to date, none have involved the cerebellum. To our knowledge, the tumor described herein represents the first case of cerebellar granular cell astrocytoma. Pathologic features and diagnostic pitfalls are explored.",
author = "Ali Saad and Jun Mo and Lili Miles and David Witte",
year = "2006",
month = "10",
day = "1",
doi = "10.1309/M67J-9YF5-K43A-Q5KC",
language = "English (US)",
volume = "126",
pages = "602--607",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "4",

}

TY - JOUR

T1 - Granular cell astrocytoma of the cerebellum

T2 - Report of the first case

AU - Saad, Ali

AU - Mo, Jun

AU - Miles, Lili

AU - Witte, David

PY - 2006/10/1

Y1 - 2006/10/1

N2 - Granular cell astrocytomas are an uncommon morphologic variant of infiltrating gliomas characterized by relatively large tumor cells with granular cytoplasm occupying variable proportions of the tumor. These tumors are thought to be more aggressive than similar tumors with no granular cell component. The tumor occurred in a 9-year-old girl who was immunocompromised owing to liver transplantation. Histologically, the tumor corresponded to World Health Organization grade II. It extensively infiltrated the cerebellum and was composed, predominantly, of large cells with eosinophilic granular cytoplasm. These cells coexpressed glial fibrillary acidic protein and CD68. Of the 49 cases of granular cell astrocytomas reported to date, none have involved the cerebellum. To our knowledge, the tumor described herein represents the first case of cerebellar granular cell astrocytoma. Pathologic features and diagnostic pitfalls are explored.

AB - Granular cell astrocytomas are an uncommon morphologic variant of infiltrating gliomas characterized by relatively large tumor cells with granular cytoplasm occupying variable proportions of the tumor. These tumors are thought to be more aggressive than similar tumors with no granular cell component. The tumor occurred in a 9-year-old girl who was immunocompromised owing to liver transplantation. Histologically, the tumor corresponded to World Health Organization grade II. It extensively infiltrated the cerebellum and was composed, predominantly, of large cells with eosinophilic granular cytoplasm. These cells coexpressed glial fibrillary acidic protein and CD68. Of the 49 cases of granular cell astrocytomas reported to date, none have involved the cerebellum. To our knowledge, the tumor described herein represents the first case of cerebellar granular cell astrocytoma. Pathologic features and diagnostic pitfalls are explored.

UR - http://www.scopus.com/inward/record.url?scp=33749328101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749328101&partnerID=8YFLogxK

U2 - 10.1309/M67J-9YF5-K43A-Q5KC

DO - 10.1309/M67J-9YF5-K43A-Q5KC

M3 - Article

C2 - 16938663

AN - SCOPUS:33749328101

VL - 126

SP - 602

EP - 607

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 4

ER -