Group I metabotropic glutamate receptors in the medial prefrontal cortex

Role in mesocorticolimbic glutamate release in cocaine sensitization

Kristin M. Timmer, Jeffery Steketee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cocaine sensitization is associated with increased excitability of pyramidal projection neurons in the medial prefrontal cortex. Such hyperexcitability is presumed to increase glutamatergic input to the nucleus accumbens and ventral tegmental area. This study examined the effects of medial prefrontal cortex Group I metabotropic glutamate receptor activation on glutamate levels in the medial prefrontal cortex, nucleus accumbens, and ventral tegmental area in sensitized and control animals. Male Sprague-Dawley rats received four daily injections of cocaine (15 mg/kg, i.p.) or saline (1 mL/kg i.p.). One, 7, or 21 days from the fourth injection, dual-probe microdialysis experiments were performed wherein Group I metabotropic glutamate receptor agonist DHPG was infused into the medial prefrontal cortex and glutamate levels in this region as well as the nucleus accumbens or ventral tegmental area were examined. Intra-mPFC DHPG infusion increased glutamate levels in the medial prefrontal cortex at 1 and 7 days withdrawal, and in the nucleus accumbens at 21 days withdrawal in sensitized rats. These results suggest Group I metabotropic glutamate receptor activation may contribute to the increased excitability of medial prefrontal cortex pyramidal neurons in sensitized animals.

Original languageEnglish (US)
Pages (from-to)887-896
Number of pages10
JournalSynapse
Volume67
Issue number12
DOIs
StatePublished - Dec 1 2013

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Metabotropic Glutamate Receptors
Prefrontal Cortex
Cocaine
Glutamic Acid
Nucleus Accumbens
Ventral Tegmental Area
Pyramidal Cells
Excitatory Amino Acid Agonists
Injections
Microdialysis
Sprague Dawley Rats

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

Cite this

Group I metabotropic glutamate receptors in the medial prefrontal cortex : Role in mesocorticolimbic glutamate release in cocaine sensitization. / Timmer, Kristin M.; Steketee, Jeffery.

In: Synapse, Vol. 67, No. 12, 01.12.2013, p. 887-896.

Research output: Contribution to journalArticle

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