Habitat, species richness and hantaviruses of sigmodontine rodents within the Interior Atlantic Forest, Paraguay

Gillian Eastwood, Jeremy V. Camp, Yong Kyu Chu, Aubrey M. Sawyer, Robert D. Owen, Xueyuan Cao, Mariah K. Taylor, Leonardo Valdivieso-Torres, Richard D. Sage, Ashley Yu, Doug G. Goodin, Vicente J. Martinez Bruyn, Ryan C. McAllister, Laura Rodriguez, Evan P. William, Colleen Jonsson

Research output: Contribution to journalArticle

Abstract

Four of the nine sigmodontine tribes have species that serve as reservoirs of rodent-borne hantaviruses (RBO-HV), few have been studied in any depth. Several viruses have been associated with human cases of hantavirus pulmonary syndrome often through peridomestic exposure. Jabora (JABV) and Juquitiba (JUQV), harbored by Akodon montensis and Oligoryzomys nigripes, respectively, are endemic and sympatric in the Reserva Natural de Bosque Mbaracayú (RNBM), Paraguay, a protected area of the Interior Atlantic Forest. Rodent communities were surveyed along a 30 km stretch of the RNBM in eight vegetation classifications (Low, High, Bamboo, Riparian and Liana Forests, Bamboo Understory, Cerrado, and Meadow/Grasslands). We collected 417 rodents from which 11 species were identified; Akodon montensis was the predominant species (72%; 95%CI: 64.7%-76.3%), followed by Hylaeamys megacephalus (15% (11.2%-18.2%)) and Oligoryzomys nigripes (9% (6.6%-12.4%)). We examined the statistical associations among habitat (vegetation class) type, rodent species diversity, population structure (age, sex, and weight), and prevalence of RBO-HV antibody and/or viral RNA (Ab/RNA) or characteristic Leishmania tail lesions. Ab/RNA positive rodents were not observed in Cerrado and Low Forest. A. montensis had an overall Ab/RNA prevalence of 7.7% (4.9%-11.3%) and O. nigripes had an overall prevalence of 8.6% (1.8%-23.1%). For A. montensis, the odds of being Ab/RNA positive in High Forest was 3.73 times of the other habitats combined. There was no significant difference among age classes in the proportion of Ab/RNA positive rodents overall (p = 0.66), however, all 11 RNA-positive individuals were adult. Sex and habitat had independent prognostic value for hantaviral Ab/RNA in the study population; age, presence of tail scar/lesion (19% of the rodents) and weight did not. Adjusting for habitat, female rodents had less risk of becoming infected. Importantly, these data suggest habitat preferences of two sympatric rodent reservoirs for two endemic hantaviruses and the importance of including habitat in models of species diversity and habitat fragmentation.

Original languageEnglish (US)
Article numbere0201307
JournalPloS one
Volume13
Issue number8
DOIs
StatePublished - Aug 1 2018

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Paraguay
Hantavirus
Ecosystem
Rodentia
rodents
Viral RNA
species diversity
habitats
RNA
antibodies
Antibodies
Oligoryzomys
lesions (plant)
Bamboo
Biodiversity
cerrado
bamboos
Tail
tail
Hantavirus Pulmonary Syndrome

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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Habitat, species richness and hantaviruses of sigmodontine rodents within the Interior Atlantic Forest, Paraguay. / Eastwood, Gillian; Camp, Jeremy V.; Chu, Yong Kyu; Sawyer, Aubrey M.; Owen, Robert D.; Cao, Xueyuan; Taylor, Mariah K.; Valdivieso-Torres, Leonardo; Sage, Richard D.; Yu, Ashley; Goodin, Doug G.; Martinez Bruyn, Vicente J.; McAllister, Ryan C.; Rodriguez, Laura; William, Evan P.; Jonsson, Colleen.

In: PloS one, Vol. 13, No. 8, e0201307, 01.08.2018.

Research output: Contribution to journalArticle

Eastwood, G, Camp, JV, Chu, YK, Sawyer, AM, Owen, RD, Cao, X, Taylor, MK, Valdivieso-Torres, L, Sage, RD, Yu, A, Goodin, DG, Martinez Bruyn, VJ, McAllister, RC, Rodriguez, L, William, EP & Jonsson, C 2018, 'Habitat, species richness and hantaviruses of sigmodontine rodents within the Interior Atlantic Forest, Paraguay', PloS one, vol. 13, no. 8, e0201307. https://doi.org/10.1371/journal.pone.0201307
Eastwood, Gillian ; Camp, Jeremy V. ; Chu, Yong Kyu ; Sawyer, Aubrey M. ; Owen, Robert D. ; Cao, Xueyuan ; Taylor, Mariah K. ; Valdivieso-Torres, Leonardo ; Sage, Richard D. ; Yu, Ashley ; Goodin, Doug G. ; Martinez Bruyn, Vicente J. ; McAllister, Ryan C. ; Rodriguez, Laura ; William, Evan P. ; Jonsson, Colleen. / Habitat, species richness and hantaviruses of sigmodontine rodents within the Interior Atlantic Forest, Paraguay. In: PloS one. 2018 ; Vol. 13, No. 8.
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AU - Eastwood, Gillian

AU - Camp, Jeremy V.

AU - Chu, Yong Kyu

AU - Sawyer, Aubrey M.

AU - Owen, Robert D.

AU - Cao, Xueyuan

AU - Taylor, Mariah K.

AU - Valdivieso-Torres, Leonardo

AU - Sage, Richard D.

AU - Yu, Ashley

AU - Goodin, Doug G.

AU - Martinez Bruyn, Vicente J.

AU - McAllister, Ryan C.

AU - Rodriguez, Laura

AU - William, Evan P.

AU - Jonsson, Colleen

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N2 - Four of the nine sigmodontine tribes have species that serve as reservoirs of rodent-borne hantaviruses (RBO-HV), few have been studied in any depth. Several viruses have been associated with human cases of hantavirus pulmonary syndrome often through peridomestic exposure. Jabora (JABV) and Juquitiba (JUQV), harbored by Akodon montensis and Oligoryzomys nigripes, respectively, are endemic and sympatric in the Reserva Natural de Bosque Mbaracayú (RNBM), Paraguay, a protected area of the Interior Atlantic Forest. Rodent communities were surveyed along a 30 km stretch of the RNBM in eight vegetation classifications (Low, High, Bamboo, Riparian and Liana Forests, Bamboo Understory, Cerrado, and Meadow/Grasslands). We collected 417 rodents from which 11 species were identified; Akodon montensis was the predominant species (72%; 95%CI: 64.7%-76.3%), followed by Hylaeamys megacephalus (15% (11.2%-18.2%)) and Oligoryzomys nigripes (9% (6.6%-12.4%)). We examined the statistical associations among habitat (vegetation class) type, rodent species diversity, population structure (age, sex, and weight), and prevalence of RBO-HV antibody and/or viral RNA (Ab/RNA) or characteristic Leishmania tail lesions. Ab/RNA positive rodents were not observed in Cerrado and Low Forest. A. montensis had an overall Ab/RNA prevalence of 7.7% (4.9%-11.3%) and O. nigripes had an overall prevalence of 8.6% (1.8%-23.1%). For A. montensis, the odds of being Ab/RNA positive in High Forest was 3.73 times of the other habitats combined. There was no significant difference among age classes in the proportion of Ab/RNA positive rodents overall (p = 0.66), however, all 11 RNA-positive individuals were adult. Sex and habitat had independent prognostic value for hantaviral Ab/RNA in the study population; age, presence of tail scar/lesion (19% of the rodents) and weight did not. Adjusting for habitat, female rodents had less risk of becoming infected. Importantly, these data suggest habitat preferences of two sympatric rodent reservoirs for two endemic hantaviruses and the importance of including habitat in models of species diversity and habitat fragmentation.

AB - Four of the nine sigmodontine tribes have species that serve as reservoirs of rodent-borne hantaviruses (RBO-HV), few have been studied in any depth. Several viruses have been associated with human cases of hantavirus pulmonary syndrome often through peridomestic exposure. Jabora (JABV) and Juquitiba (JUQV), harbored by Akodon montensis and Oligoryzomys nigripes, respectively, are endemic and sympatric in the Reserva Natural de Bosque Mbaracayú (RNBM), Paraguay, a protected area of the Interior Atlantic Forest. Rodent communities were surveyed along a 30 km stretch of the RNBM in eight vegetation classifications (Low, High, Bamboo, Riparian and Liana Forests, Bamboo Understory, Cerrado, and Meadow/Grasslands). We collected 417 rodents from which 11 species were identified; Akodon montensis was the predominant species (72%; 95%CI: 64.7%-76.3%), followed by Hylaeamys megacephalus (15% (11.2%-18.2%)) and Oligoryzomys nigripes (9% (6.6%-12.4%)). We examined the statistical associations among habitat (vegetation class) type, rodent species diversity, population structure (age, sex, and weight), and prevalence of RBO-HV antibody and/or viral RNA (Ab/RNA) or characteristic Leishmania tail lesions. Ab/RNA positive rodents were not observed in Cerrado and Low Forest. A. montensis had an overall Ab/RNA prevalence of 7.7% (4.9%-11.3%) and O. nigripes had an overall prevalence of 8.6% (1.8%-23.1%). For A. montensis, the odds of being Ab/RNA positive in High Forest was 3.73 times of the other habitats combined. There was no significant difference among age classes in the proportion of Ab/RNA positive rodents overall (p = 0.66), however, all 11 RNA-positive individuals were adult. Sex and habitat had independent prognostic value for hantaviral Ab/RNA in the study population; age, presence of tail scar/lesion (19% of the rodents) and weight did not. Adjusting for habitat, female rodents had less risk of becoming infected. Importantly, these data suggest habitat preferences of two sympatric rodent reservoirs for two endemic hantaviruses and the importance of including habitat in models of species diversity and habitat fragmentation.

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