Haemangiomas in kidneys with end-stage renal disease

A novel clinicopathological association

Oleksandr N. Kryvenko, Susan L. Haley, Steven C. Smith, Steven S. Shen, Swetha Paluru, Nilesh S. Gupta, Merce Jorda, Jonathan I. Epstein, Mahul Amin, Luan D. Truong

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Aims: The study of haemangiomas in end-stage renal disease (ESRD). Methods and results: Twenty ESRD nephrectomies from 16 patients (aged 9 months-68 years) were due to hypertension (four), focal segmental glomerulosclerosis (four), lupus nephritis (three), diabetes (one), IgA nephropathy (one), hereditary nephritis (one), congenital nephrotic syndrome (one) and unknown cause (one). Haemangiomas appeared as a single mass (15), two masses (one), three masses (one), four masses (two) and eight masses (one) per kidney. Tumours measured 0.2-3.5 cm. Four patients had bilateral haemangiomas. All tumours were in the medulla and often abutted renal sinus fat. All except one of the tumours were anastomosing haemangiomas, showing isolated or interconnected sinusoidal capillary-sized vascular channels lined by a single layer of benign cuboidal CD34+, CD31+, D2-40- endothelial cells, separated by loose stroma with spindle cells. One tumour was a cellular capillary haemangioma. Intravascular growth was seen in nine specimens. All haemangiomas had extramedullary haematopoiesis. Acquired cystic kidney disease (ACKD) was seen in 11 kidneys (nine patients), renal cell carcinoma (RCC) in five, ACKD-associated RCC precursors in three, Wilms' tumour in one and papillary adenomas in five. Conclusions: Anastomosing haemangioma appears as a distinctive clinicopathological entity developing in kidneys with ESRD, with or without ACKD.

Original languageEnglish (US)
Pages (from-to)309-318
Number of pages10
JournalHistopathology
Volume65
Issue number3
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Hemangioma
Chronic Kidney Failure
Cystic Kidney Diseases
Kidney
Renal Cell Carcinoma
Neoplasms
Capillary Hemangioma
Extramedullary Hematopoiesis
Hereditary Nephritis
Focal Segmental Glomerulosclerosis
Lupus Nephritis
Wilms Tumor
Nephrotic Syndrome
Nephrectomy
Adenoma
Immunoglobulin A
Blood Vessels
Endothelial Cells
Fats
Hypertension

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

Cite this

Kryvenko, O. N., Haley, S. L., Smith, S. C., Shen, S. S., Paluru, S., Gupta, N. S., ... Truong, L. D. (2014). Haemangiomas in kidneys with end-stage renal disease: A novel clinicopathological association. Histopathology, 65(3), 309-318. https://doi.org/10.1111/his.12394

Haemangiomas in kidneys with end-stage renal disease : A novel clinicopathological association. / Kryvenko, Oleksandr N.; Haley, Susan L.; Smith, Steven C.; Shen, Steven S.; Paluru, Swetha; Gupta, Nilesh S.; Jorda, Merce; Epstein, Jonathan I.; Amin, Mahul; Truong, Luan D.

In: Histopathology, Vol. 65, No. 3, 01.01.2014, p. 309-318.

Research output: Contribution to journalArticle

Kryvenko, ON, Haley, SL, Smith, SC, Shen, SS, Paluru, S, Gupta, NS, Jorda, M, Epstein, JI, Amin, M & Truong, LD 2014, 'Haemangiomas in kidneys with end-stage renal disease: A novel clinicopathological association', Histopathology, vol. 65, no. 3, pp. 309-318. https://doi.org/10.1111/his.12394
Kryvenko ON, Haley SL, Smith SC, Shen SS, Paluru S, Gupta NS et al. Haemangiomas in kidneys with end-stage renal disease: A novel clinicopathological association. Histopathology. 2014 Jan 1;65(3):309-318. https://doi.org/10.1111/his.12394
Kryvenko, Oleksandr N. ; Haley, Susan L. ; Smith, Steven C. ; Shen, Steven S. ; Paluru, Swetha ; Gupta, Nilesh S. ; Jorda, Merce ; Epstein, Jonathan I. ; Amin, Mahul ; Truong, Luan D. / Haemangiomas in kidneys with end-stage renal disease : A novel clinicopathological association. In: Histopathology. 2014 ; Vol. 65, No. 3. pp. 309-318.
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