Harmful effects of antioxidant therapy

Adam F. Stewart, Edward Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Oxidative stress has an integral role in the pathophysiology of most human diseases. With a rapidly aging population, increased attention and study have been directed toward the use of antioxidant therapy. The appeal is that these agents are considered “natural” substances and are associated with a healthy diet. The hypothesis has been that decreasing oxidative stress may prevent disease processes such as cancer or coronary heart disease. Because much of the general population use is in relatively healthy patients, it is critically important that these supplements are free of toxicity and side effects. While initial studies of antioxidant supplementation suggested a beneficial role in disease prevention, more recent clinical trials and a meta-analysis have questioned the benefit of these therapies. Several studies have suggested that excess supplementation may in fact be harmful. Recent attention has also focused on the use of antioxidants for the treatment of male infertility. The focus of this chapter is the potentially harmful effects of antioxidant therapy.

Original languageEnglish (US)
Title of host publicationMale Infertility
Subtitle of host publicationContemporary Clinical Approaches, Andrology, ART and Antioxidants
PublisherSpringer New York
Pages499-506
Number of pages8
ISBN (Electronic)9781461433354
ISBN (Print)9781461433347
DOIs
StatePublished - Jan 1 2012

Fingerprint

Antioxidants
Oxidative Stress
Male Infertility
Therapeutics
Population
Coronary Disease
Meta-Analysis
Clinical Trials
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Stewart, A. F., & Kim, E. (2012). Harmful effects of antioxidant therapy. In Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants (pp. 499-506). Springer New York. https://doi.org/10.1007/978-1-4614-3335-4_47

Harmful effects of antioxidant therapy. / Stewart, Adam F.; Kim, Edward.

Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants. Springer New York, 2012. p. 499-506.

Research output: Chapter in Book/Report/Conference proceedingChapter

Stewart, AF & Kim, E 2012, Harmful effects of antioxidant therapy. in Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants. Springer New York, pp. 499-506. https://doi.org/10.1007/978-1-4614-3335-4_47
Stewart AF, Kim E. Harmful effects of antioxidant therapy. In Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants. Springer New York. 2012. p. 499-506 https://doi.org/10.1007/978-1-4614-3335-4_47
Stewart, Adam F. ; Kim, Edward. / Harmful effects of antioxidant therapy. Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants. Springer New York, 2012. pp. 499-506
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