Head and neck cancer

A case for inhibition by isothiocyanates and indoles from cruciferous vegetables

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Chemical carcinogens derived from cigarettes and other tobacco products, as well as betel quid, paan, and alcohol consumption, are commonly associated with head and neck cancer risk. This is a particularly debilitating cancer, with a high recurrence rate and long-term treatment comorbidities affecting health and lifestyle. Controlling tobacco access or use may be an ideal prevention strategy but may also be challenging or undesired. Individuals, however, may be able to reduce their risk through simple and focused dietary change. Results from epidemiologic studies, basic research, and clinical investigations suggest that a diet rich in cruciferous vegetables may increase carcinogen metabolism, induce apoptosis, and reduce the risk of developing a primary head and neck tumor. This review briefly summarizes head and neck cancer nutritional epidemiology, and then describes the biochemical and epidemiologic literature describing the effects of crucifer consumption on head and neck carcinogenesis. To translate these findings, the strengths and limitations of specific intervention models are discussed, including differences in target populations and the choice of a food-based or pill-based approach for intervention. Addressing these factors in a future intervention may define a low-cost and non-toxic approach to reduce the burden of head and neck cancer.

Original languageEnglish (US)
Pages (from-to)348-356
Number of pages9
JournalEuropean Journal of Cancer Prevention
Volume16
Issue number4
DOIs
StatePublished - Aug 1 2007

Fingerprint

Isothiocyanates
Indoles
Head and Neck Neoplasms
Vegetables
Tobacco Products
Carcinogens
Neck
Head
Health Services Needs and Demand
Alcohol Drinking
Tobacco
Life Style
Comorbidity
Epidemiologic Studies
Neoplasms
Carcinogenesis
Epidemiology
Apoptosis
Diet
Costs and Cost Analysis

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Head and neck cancer : A case for inhibition by isothiocyanates and indoles from cruciferous vegetables. / Fowke, Jay.

In: European Journal of Cancer Prevention, Vol. 16, No. 4, 01.08.2007, p. 348-356.

Research output: Contribution to journalReview article

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