Headache types, related morbidity, and quality of life in survivors of childhood acute lymphoblastic leukemia: A prospective cross sectional study

Zsila S. Sadighi, Kirsten K. Ness, Melissa M. Hudson, E. Brannon Morris, Davonna S. Ledet, Ching Hon Pui, Scott Howard, Kevin R. Krull, Emily Browne, Debbie Crom, Pamela S. Hinds, Liang Zhu, Deokumar Srivastava, Raja B. Khan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background Increased headache prevalence was recently reported in survivors of childhood ALL. Headache sub types, related morbidity, and effect on quality of life has not been reported thus far.

Objective To study headache prevalence and type, related disability, and quality of life in a cohort of childhood acute lymphoblastic leukemia (ALL) survivors.

Methods Childhood ALL survivors in at least 1-year of remission and 5 years from diagnosis completed questionnaires and were evaluated by a neurologist. Disability was evaluated with Pediatric Migraine Disability Assessment scale and the Short Form-36 Health Survey assessed quality of life.

Results Thirty nine of 72 (54%) females and 37 of 90 (41%) males reported headaches. Median time from ALL diagnosis to first headache was 5.2 years and median age at headache onset was 10.1 years in 76 participants with headache. Migraine headaches were diagnosed in 51 (31%) and episodic tension-type headaches in 49 (30%); migraine and tension-type headaches co-existed in 24 (15%) and 18 (11%) participants had chronic daily headaches. Fatigue was associated with migraine headache while hypertension and female gender associated with tension type headache. Headache-related disability was mild in 22 (29%), moderate in 7 (9%), and severe in 5 (7%) survivors, and was absent in the remaining 42 (55%) survivors with headache. Both migraine and tension type headaches associated with reduced mental component scores, while headache related disability associated with a reduced physical component scores.

Conclusions Headaches are common in ALL survivors but only a minority has significant disability or impairment of quality of life.

Original languageEnglish (US)
Pages (from-to)722-729
Number of pages8
JournalEuropean Journal of Paediatric Neurology
Volume18
Issue number6
DOIs
StatePublished - Nov 1 2014

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Headache
Survivors
Cross-Sectional Studies
Quality of Life
Morbidity
Tension-Type Headache
Migraine Disorders
Headache Disorders
Health Surveys
Age of Onset
Fatigue
Pediatrics
Hypertension

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Headache types, related morbidity, and quality of life in survivors of childhood acute lymphoblastic leukemia : A prospective cross sectional study. / Sadighi, Zsila S.; Ness, Kirsten K.; Hudson, Melissa M.; Morris, E. Brannon; Ledet, Davonna S.; Pui, Ching Hon; Howard, Scott; Krull, Kevin R.; Browne, Emily; Crom, Debbie; Hinds, Pamela S.; Zhu, Liang; Srivastava, Deokumar; Khan, Raja B.

In: European Journal of Paediatric Neurology, Vol. 18, No. 6, 01.11.2014, p. 722-729.

Research output: Contribution to journalArticle

Sadighi, ZS, Ness, KK, Hudson, MM, Morris, EB, Ledet, DS, Pui, CH, Howard, S, Krull, KR, Browne, E, Crom, D, Hinds, PS, Zhu, L, Srivastava, D & Khan, RB 2014, 'Headache types, related morbidity, and quality of life in survivors of childhood acute lymphoblastic leukemia: A prospective cross sectional study', European Journal of Paediatric Neurology, vol. 18, no. 6, pp. 722-729. https://doi.org/10.1016/j.ejpn.2014.06.006
Sadighi, Zsila S. ; Ness, Kirsten K. ; Hudson, Melissa M. ; Morris, E. Brannon ; Ledet, Davonna S. ; Pui, Ching Hon ; Howard, Scott ; Krull, Kevin R. ; Browne, Emily ; Crom, Debbie ; Hinds, Pamela S. ; Zhu, Liang ; Srivastava, Deokumar ; Khan, Raja B. / Headache types, related morbidity, and quality of life in survivors of childhood acute lymphoblastic leukemia : A prospective cross sectional study. In: European Journal of Paediatric Neurology. 2014 ; Vol. 18, No. 6. pp. 722-729.
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abstract = "Background Increased headache prevalence was recently reported in survivors of childhood ALL. Headache sub types, related morbidity, and effect on quality of life has not been reported thus far.Objective To study headache prevalence and type, related disability, and quality of life in a cohort of childhood acute lymphoblastic leukemia (ALL) survivors.Methods Childhood ALL survivors in at least 1-year of remission and 5 years from diagnosis completed questionnaires and were evaluated by a neurologist. Disability was evaluated with Pediatric Migraine Disability Assessment scale and the Short Form-36 Health Survey assessed quality of life.Results Thirty nine of 72 (54{\%}) females and 37 of 90 (41{\%}) males reported headaches. Median time from ALL diagnosis to first headache was 5.2 years and median age at headache onset was 10.1 years in 76 participants with headache. Migraine headaches were diagnosed in 51 (31{\%}) and episodic tension-type headaches in 49 (30{\%}); migraine and tension-type headaches co-existed in 24 (15{\%}) and 18 (11{\%}) participants had chronic daily headaches. Fatigue was associated with migraine headache while hypertension and female gender associated with tension type headache. Headache-related disability was mild in 22 (29{\%}), moderate in 7 (9{\%}), and severe in 5 (7{\%}) survivors, and was absent in the remaining 42 (55{\%}) survivors with headache. Both migraine and tension type headaches associated with reduced mental component scores, while headache related disability associated with a reduced physical component scores.Conclusions Headaches are common in ALL survivors but only a minority has significant disability or impairment of quality of life.",
author = "Sadighi, {Zsila S.} and Ness, {Kirsten K.} and Hudson, {Melissa M.} and Morris, {E. Brannon} and Ledet, {Davonna S.} and Pui, {Ching Hon} and Scott Howard and Krull, {Kevin R.} and Emily Browne and Debbie Crom and Hinds, {Pamela S.} and Liang Zhu and Deokumar Srivastava and Khan, {Raja B.}",
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T1 - Headache types, related morbidity, and quality of life in survivors of childhood acute lymphoblastic leukemia

T2 - A prospective cross sectional study

AU - Sadighi, Zsila S.

AU - Ness, Kirsten K.

AU - Hudson, Melissa M.

AU - Morris, E. Brannon

AU - Ledet, Davonna S.

AU - Pui, Ching Hon

AU - Howard, Scott

AU - Krull, Kevin R.

AU - Browne, Emily

AU - Crom, Debbie

AU - Hinds, Pamela S.

AU - Zhu, Liang

AU - Srivastava, Deokumar

AU - Khan, Raja B.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Background Increased headache prevalence was recently reported in survivors of childhood ALL. Headache sub types, related morbidity, and effect on quality of life has not been reported thus far.Objective To study headache prevalence and type, related disability, and quality of life in a cohort of childhood acute lymphoblastic leukemia (ALL) survivors.Methods Childhood ALL survivors in at least 1-year of remission and 5 years from diagnosis completed questionnaires and were evaluated by a neurologist. Disability was evaluated with Pediatric Migraine Disability Assessment scale and the Short Form-36 Health Survey assessed quality of life.Results Thirty nine of 72 (54%) females and 37 of 90 (41%) males reported headaches. Median time from ALL diagnosis to first headache was 5.2 years and median age at headache onset was 10.1 years in 76 participants with headache. Migraine headaches were diagnosed in 51 (31%) and episodic tension-type headaches in 49 (30%); migraine and tension-type headaches co-existed in 24 (15%) and 18 (11%) participants had chronic daily headaches. Fatigue was associated with migraine headache while hypertension and female gender associated with tension type headache. Headache-related disability was mild in 22 (29%), moderate in 7 (9%), and severe in 5 (7%) survivors, and was absent in the remaining 42 (55%) survivors with headache. Both migraine and tension type headaches associated with reduced mental component scores, while headache related disability associated with a reduced physical component scores.Conclusions Headaches are common in ALL survivors but only a minority has significant disability or impairment of quality of life.

AB - Background Increased headache prevalence was recently reported in survivors of childhood ALL. Headache sub types, related morbidity, and effect on quality of life has not been reported thus far.Objective To study headache prevalence and type, related disability, and quality of life in a cohort of childhood acute lymphoblastic leukemia (ALL) survivors.Methods Childhood ALL survivors in at least 1-year of remission and 5 years from diagnosis completed questionnaires and were evaluated by a neurologist. Disability was evaluated with Pediatric Migraine Disability Assessment scale and the Short Form-36 Health Survey assessed quality of life.Results Thirty nine of 72 (54%) females and 37 of 90 (41%) males reported headaches. Median time from ALL diagnosis to first headache was 5.2 years and median age at headache onset was 10.1 years in 76 participants with headache. Migraine headaches were diagnosed in 51 (31%) and episodic tension-type headaches in 49 (30%); migraine and tension-type headaches co-existed in 24 (15%) and 18 (11%) participants had chronic daily headaches. Fatigue was associated with migraine headache while hypertension and female gender associated with tension type headache. Headache-related disability was mild in 22 (29%), moderate in 7 (9%), and severe in 5 (7%) survivors, and was absent in the remaining 42 (55%) survivors with headache. Both migraine and tension type headaches associated with reduced mental component scores, while headache related disability associated with a reduced physical component scores.Conclusions Headaches are common in ALL survivors but only a minority has significant disability or impairment of quality of life.

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DO - 10.1016/j.ejpn.2014.06.006

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JO - European Journal of Paediatric Neurology

JF - European Journal of Paediatric Neurology

SN - 1090-3798

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