Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis

Nader Tanideh, Parisa Tavakoli, Mohammad Ali Saghiri, Franklin Garcia-Godoy, Dariush Amanat, Azadeh Andisheh Tadbir, Soleiman Mohammadi Samani, Amin Tamadon

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: This study assessed the potential of topical Calendula officinalis extract on the healing of oral mucositis induced by 5-fluorouracil (5-FU) in hamsters. Study Design: Oral mucositis was induced in 60 male hamsters by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle on days 1 and 2. On days 12-17, 5% and 10% C. officinalis gel and gel base groups were treated and then compared with a control group. Macroscopic and microscopic scores and weights were evaluated. Results: Microscopic and macroscopic scores of mucositis were lower in the 5% and 10% C. officinalis gel groups than in the gel base and control groups (P <.05). Weight gain was noted in the treatment groups compared with the gel base and control groups (P <.05). Conclusions: Calendula officinalis extract accelerated the healing of oral mucositis in hamsters.

Original languageEnglish (US)
Pages (from-to)332-338
Number of pages7
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume115
Issue number3
DOIs
StatePublished - Mar 1 2013

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Calendula
Stomatitis
Fluorouracil
Cricetinae
Gels
Control Groups
Mucositis
Cheek
Weight Gain
Needles
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

Cite this

Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis. / Tanideh, Nader; Tavakoli, Parisa; Saghiri, Mohammad Ali; Garcia-Godoy, Franklin; Amanat, Dariush; Tadbir, Azadeh Andisheh; Samani, Soleiman Mohammadi; Tamadon, Amin.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 115, No. 3, 01.03.2013, p. 332-338.

Research output: Contribution to journalArticle

Tanideh, Nader ; Tavakoli, Parisa ; Saghiri, Mohammad Ali ; Garcia-Godoy, Franklin ; Amanat, Dariush ; Tadbir, Azadeh Andisheh ; Samani, Soleiman Mohammadi ; Tamadon, Amin. / Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis. In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2013 ; Vol. 115, No. 3. pp. 332-338.
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N2 - Objective: This study assessed the potential of topical Calendula officinalis extract on the healing of oral mucositis induced by 5-fluorouracil (5-FU) in hamsters. Study Design: Oral mucositis was induced in 60 male hamsters by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle on days 1 and 2. On days 12-17, 5% and 10% C. officinalis gel and gel base groups were treated and then compared with a control group. Macroscopic and microscopic scores and weights were evaluated. Results: Microscopic and macroscopic scores of mucositis were lower in the 5% and 10% C. officinalis gel groups than in the gel base and control groups (P <.05). Weight gain was noted in the treatment groups compared with the gel base and control groups (P <.05). Conclusions: Calendula officinalis extract accelerated the healing of oral mucositis in hamsters.

AB - Objective: This study assessed the potential of topical Calendula officinalis extract on the healing of oral mucositis induced by 5-fluorouracil (5-FU) in hamsters. Study Design: Oral mucositis was induced in 60 male hamsters by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle on days 1 and 2. On days 12-17, 5% and 10% C. officinalis gel and gel base groups were treated and then compared with a control group. Macroscopic and microscopic scores and weights were evaluated. Results: Microscopic and macroscopic scores of mucositis were lower in the 5% and 10% C. officinalis gel groups than in the gel base and control groups (P <.05). Weight gain was noted in the treatment groups compared with the gel base and control groups (P <.05). Conclusions: Calendula officinalis extract accelerated the healing of oral mucositis in hamsters.

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