Health status and health-related quality of life in long-term adult survivors of pediatric solid tumors

Deborah B. Crom, Donna K. Chathaway, Elizabeth Tolley, Raymond K. Mulhern, Melissa M. Hudson

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

We have examined the influence of selected factors (gender, marital status, socio-economic status, co-morbid conditions, access to medical care, age at diagnosis, intensity of therapy and time since diagnosis) on subsequent health status and health-related quality of life (HRQL) of long-term survivors of pédiatrie solid tumors. Two hundred and twenty individuals who had survived a pédiatrie solid tumor 15 years or longer completed telephone and written assessments of their current status. Health status was assessed using the Late Effects of Normal Tissues toxicity scale. HRQL was investigated using the Ferrans and Powers Quality of Life Index-Cancer (QLIC) and the EORTC Quality of Life Questionnaire C30 (QLQ-C30). Results indicated that health status and HRQL were better in survivors treated with lowintensity therapy. One hundred and thirty respondents (59.1%) reported at least I serious toxicity. Dyspnea and fatigue were commonly reported in survivors of Hodgkin's disease. Correlational analyses showed that predictors of health status included socio-economic status, marital status and the presence of co-morbid factors. Mean HRQL scores for the 4 domains of the Ferrans and Powers QLIC and the functional scales of the EORTC QLQ-C30 indicated that most of the survivors were experiencing moderately good to excellent HRQL. One-third of survivors reported that their history of cancer had an adverse impact on their current financial status. Prediction models constructed for 3 of the domains from the 2 HRQL instruments are presented (health and functioning, global HRQL and financial impact). Within these 3 models, consistent predictors of HRQL outcomes included health status, presence of dyspnea or pain, marital status and socio-economic status.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalInternational Journal of Cancer
Volume83
Issue numberSUPPL. 12
StatePublished - Dec 1 1999

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Health Status
Survivors
Quality of Life
Pediatrics
Neoplasms
Marital Status
Economics
Dyspnea
Hodgkin Disease
Telephone
Fatigue
Pain
Health

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Health status and health-related quality of life in long-term adult survivors of pediatric solid tumors. / Crom, Deborah B.; Chathaway, Donna K.; Tolley, Elizabeth; Mulhern, Raymond K.; Hudson, Melissa M.

In: International Journal of Cancer, Vol. 83, No. SUPPL. 12, 01.12.1999, p. 25-31.

Research output: Contribution to journalArticle

Crom, Deborah B. ; Chathaway, Donna K. ; Tolley, Elizabeth ; Mulhern, Raymond K. ; Hudson, Melissa M. / Health status and health-related quality of life in long-term adult survivors of pediatric solid tumors. In: International Journal of Cancer. 1999 ; Vol. 83, No. SUPPL. 12. pp. 25-31.
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