La funzione cardiaca nel sovraccarico cronico di pressione da stenosi aortica

ruolo del tessuto collagene.

Translated title of the contribution: Heart function in chronic pressure overload caused by aortic stenosis: the role of collagen tissue

B. Villari, O. M. Hess, F. Piscione, G. Vassalli, Karl Weber, M. Chiariello

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The purpose of this study was to evaluate left ventricular (LV) structure-function interplay in aortic stenosis. LV structure was assessed from endomyocardial biopsies obtained in 27 patients with aortic stenosis. Total collagen volume fraction, orthogonal collagen fiber meshwork (cross-hatching) and endocardial fibrosis were determined by morphologic-morphometric evaluation. Control biopsy data were obtained from 6 pre-transplantation donor hearts whereas other 11 patients with normal cardiac function served as hemodynamic controls. LV biplane cineangiography and high-fidelity LV pressure measurement were carried out in all patients. Systolic function was assessed by LV biplane ejection fraction, diastolic function by time constant of relaxation, peak filling rates and passive elastic properties. Total collagen volume fraction (7.3 versus 1.6%, p < 0.01) as well as the degree of cross-hatching (1.7 versus 0.8 grade, p < 0.01) were significantly increased in patients with aortic stenosis with respect to controls. Endocardial fibrosis was present in 11/27 patients with aortic stenosis and in no patients of control group. In aortic stenosis in presence of increased total collagen volume fraction there were no changes in systolic and diastolic function, whereas in presence of changes in collagen architecture ejection fraction was depressed and passive elastic properties increased. In conclusion, in aortic stenosis, changes in collagen architecture are associated with altered systolic function and passive diastolic properties. The sole increase in total collagen volume fraction without a change in architecture leaves systolic and passive diastolic function unaltered. A prolongation of relaxation was present in aortic stenosis and appears to be mediated by muscle hypertrophy per se.

Original languageItalian
Pages (from-to)411-420
Number of pages10
JournalCardiologia (Rome, Italy)
Volume39
Issue number6
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Aortic Valve Stenosis
Collagen
Pressure
Fibrosis
Cineangiography
Biopsy
Ventricular Pressure
Heart Transplantation
Left Ventricular Function
Stroke Volume
Hypertrophy
Hemodynamics
Tissue Donors
Muscles
Control Groups

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Villari, B., Hess, O. M., Piscione, F., Vassalli, G., Weber, K., & Chiariello, M. (1994). La funzione cardiaca nel sovraccarico cronico di pressione da stenosi aortica: ruolo del tessuto collagene. Cardiologia (Rome, Italy), 39(6), 411-420.

La funzione cardiaca nel sovraccarico cronico di pressione da stenosi aortica : ruolo del tessuto collagene. / Villari, B.; Hess, O. M.; Piscione, F.; Vassalli, G.; Weber, Karl; Chiariello, M.

In: Cardiologia (Rome, Italy), Vol. 39, No. 6, 01.01.1994, p. 411-420.

Research output: Contribution to journalArticle

Villari, B, Hess, OM, Piscione, F, Vassalli, G, Weber, K & Chiariello, M 1994, 'La funzione cardiaca nel sovraccarico cronico di pressione da stenosi aortica: ruolo del tessuto collagene.', Cardiologia (Rome, Italy), vol. 39, no. 6, pp. 411-420.
Villari, B. ; Hess, O. M. ; Piscione, F. ; Vassalli, G. ; Weber, Karl ; Chiariello, M. / La funzione cardiaca nel sovraccarico cronico di pressione da stenosi aortica : ruolo del tessuto collagene. In: Cardiologia (Rome, Italy). 1994 ; Vol. 39, No. 6. pp. 411-420.
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