Heart Rate Variability in Rats with Aldosterone-Induced Chronic Heart Failure

P. Raphisak, Amy Curry, R. A. Malkin, S. A.C. Schuckers

Research output: Contribution to journalConference article

1 Citation (Scopus)

Abstract

The renin-angiotensin-aldosterone system contributes to the pathophysiology of chronic heart failure. In this study, chronic heart failure is gradually induced in uninephrectomized rats (n = 4) by aldosterone infusion (0.75 μg/h) and high Na and low Mg diet for four weeks followed up by high Na and low Mg diet alone for an additional six weeks. A control rat (n = 1) is untreated and unoperated. Electrocardiograms were recorded continuously during the entire experiment. Time and frequency domain heart rate variability (HRV) parameters are computed to study the long-term trends of heart rate and HRV. The results show that aldosterone infusion decreases heart rate and circadian variability in the treatment rats. After stopping aldosterone infusion, heart rate increases with less circadian variability. ANOVA indicates change of heart rate (p < 0.001) during and after aldosterone infusion periods (within each treatment rat).

Original languageEnglish (US)
Pages (from-to)228-231
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
StatePublished - Dec 1 2003
EventA New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: Sep 17 2003Sep 21 2003

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Aldosterone
Rats
Heart Failure
Heart Rate
Nutrition
Diet
Rat control
Renin-Angiotensin System
Analysis of Variance
Electrocardiography
Analysis of variance (ANOVA)

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Heart Rate Variability in Rats with Aldosterone-Induced Chronic Heart Failure. / Raphisak, P.; Curry, Amy; Malkin, R. A.; Schuckers, S. A.C.

In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 1, 01.12.2003, p. 228-231.

Research output: Contribution to journalConference article

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