Heat-induced superaggregation of amphotericin B attenuates its ability to induce cytokine and chemokine production in the human monocytic cell line THP-1

Phillip Rogers, Katherine S. Barker, Vanessa Herring, Melissa Jacob

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The cytokine and chemokine response elicited by heat-treated amphotericin B (HT-AmB) was compared with that of untreated amphotericin B (AmB-DOC) in the human monocyte cell line THP-1. AmB-DOC produced dose-dependent increases in interleukin (IL)-1β, IL-1α, tumour necrosis factor-α, macrophage inflammatory protein (MIP)-1α and MIP-1β at 2 h. HT-AmB induced cytokine and chemokine production at a lower level than those observed with corresponding concentrations of AmB-DOC, while retaining antifungal activity. These results indicate that heat treatment of amphotericin B may prove to be a cost-effective approach to improving the therapeutic index of this antifungal agent.

Original languageEnglish (US)
Pages (from-to)405-408
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume51
Issue number2
DOIs
StatePublished - Feb 1 2003

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Amphotericin B
Chemokines
Hot Temperature
Cytokines
Macrophage Inflammatory Proteins
Cell Line
Interleukin-1
Antifungal Agents
Monocytes
Tumor Necrosis Factor-alpha
Costs and Cost Analysis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Heat-induced superaggregation of amphotericin B attenuates its ability to induce cytokine and chemokine production in the human monocytic cell line THP-1. / Rogers, Phillip; Barker, Katherine S.; Herring, Vanessa; Jacob, Melissa.

In: Journal of Antimicrobial Chemotherapy, Vol. 51, No. 2, 01.02.2003, p. 405-408.

Research output: Contribution to journalArticle

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