Heavy metal ions in normal physiology, toxic stress, and cytoprotection

Michael A. Lynes, Yujian Kang, Stefano L. Sensi, George A. Perdrizet, Lawrence E. Hightower

Research output: Chapter in Book/Report/Conference proceedingConference contribution

42 Citations (Scopus)

Abstract

As a group, heavy metals include both those essential for normal biological functioning (e.g., Cu and Zn), and nonessential metals (e.g., Cd, Hg, and Pb). Both essential and nonessential metals can be present at concentrations that disturb normal biological functions, and which evoke cellular stress responses. The cellular targets for metal toxicity include tissues of the kidney, liver, heart, and the immune response and nervous systems. Intriguingly, manipulations of specific metals, their reservoirs, and the cellular stress response can have therapeutic effects on certain diseases. In this minireview, we will consider both the biological responses to stressful levels of heavy metal cations, and experimental and clinical manipulations of these cations as a means to improve human health parameters.

Original languageEnglish (US)
Title of host publicationStress Responses
PublisherBlackwell Publishing Inc.
Pages159-172
Number of pages14
ISBN (Print)157331675X, 9781573316750
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1113
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Fingerprint

Heavy Ions
Cytoprotection
Poisons
Physiology
Heavy Metals
Heavy ions
Metal ions
Metals
Cations
Neurology
Therapeutic Uses
Liver
Nervous System
Toxicity
Immune System
Health
Tissue
Kidney
Manipulation

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Lynes, M. A., Kang, Y., Sensi, S. L., Perdrizet, G. A., & Hightower, L. E. (2007). Heavy metal ions in normal physiology, toxic stress, and cytoprotection. In Stress Responses (pp. 159-172). (Annals of the New York Academy of Sciences; Vol. 1113). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1391.010

Heavy metal ions in normal physiology, toxic stress, and cytoprotection. / Lynes, Michael A.; Kang, Yujian; Sensi, Stefano L.; Perdrizet, George A.; Hightower, Lawrence E.

Stress Responses. Blackwell Publishing Inc., 2007. p. 159-172 (Annals of the New York Academy of Sciences; Vol. 1113).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lynes, MA, Kang, Y, Sensi, SL, Perdrizet, GA & Hightower, LE 2007, Heavy metal ions in normal physiology, toxic stress, and cytoprotection. in Stress Responses. Annals of the New York Academy of Sciences, vol. 1113, Blackwell Publishing Inc., pp. 159-172. https://doi.org/10.1196/annals.1391.010
Lynes MA, Kang Y, Sensi SL, Perdrizet GA, Hightower LE. Heavy metal ions in normal physiology, toxic stress, and cytoprotection. In Stress Responses. Blackwell Publishing Inc. 2007. p. 159-172. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1391.010
Lynes, Michael A. ; Kang, Yujian ; Sensi, Stefano L. ; Perdrizet, George A. ; Hightower, Lawrence E. / Heavy metal ions in normal physiology, toxic stress, and cytoprotection. Stress Responses. Blackwell Publishing Inc., 2007. pp. 159-172 (Annals of the New York Academy of Sciences).
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