Helicobacter pylori prevalence and circulating micronutrient levels in a low-income United States population

Meira Epplein, Lisa B. Signorello, Wei Zheng, Qiuyin Cai, Margaret K. Hargreaves, Angelika Michel, Michael Pawlita, Jay Fowke, Pelayo Correa, William J. Blot

Research output: Contribution to journalArticle

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Abstract

High prevalence of Helicobacter pylori (H. pylori), the leading cause of gastric cancer, and low levels of micronutrients have been observed in many developing countries, and the question remains as to the whether an association between the 2 exists. The present study seeks to further our understanding of this potential connection in the Southern Community Cohort Study, representing a low-income population in the United States. Blood levels of antibodies to H. pylori proteins were assessed by multiplex serology for a sample of 310 African American and white participants, ages 40 to 79 years. Blood collected at baseline was also assayed for levels of carotenoids, tocopherols, retinol, and folate. Multivariate linear regression was used to calculate least-squares mean micronutrient levels within groups defined by H. pylori status. The mean serum levels of all micronutrients assayed were lower among H. pylori+ individuals than H. pylori - individuals, significantly for β-carotene, folate, and retinol (decreases of 27.6%, 18.6%, and 9.7%, respectively). Individuals who were seropositive to the virulent CagA+ H. pylori strains had even lower mean levels of micronutrients, particularly β-carotene, folate, total carotenoids, and retinol (decreases of 38.9%, 19.1%, 17.0%, and 11.7%, respectively, compared with H. pylori- individuals). However, dietary micronutrient levels as derived from a food frequency questionnaire did not vary between groups defined by H. pylori status. These results provide support for the hypothesis that H. pylori infection impairs nutrient absorption and suggest a need for future studies to explore the role of H. pylori infection on nutrition and gastric cancer risk in this high-risk population.

Original languageEnglish (US)
Pages (from-to)871-878
Number of pages8
JournalCancer Prevention Research
Volume4
Issue number6
DOIs
StatePublished - Jun 1 2011

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Micronutrients
Helicobacter pylori
Population
Carotenoids
Vitamin A
Folic Acid
Helicobacter Infections
Stomach Neoplasms
Food
Tocopherols
Serology
Poverty
Least-Squares Analysis
African Americans
Developing Countries
Linear Models
Cohort Studies
Antibodies

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Epplein, M., Signorello, L. B., Zheng, W., Cai, Q., Hargreaves, M. K., Michel, A., ... Blot, W. J. (2011). Helicobacter pylori prevalence and circulating micronutrient levels in a low-income United States population. Cancer Prevention Research, 4(6), 871-878. https://doi.org/10.1158/1940-6207.CAPR-10-0398

Helicobacter pylori prevalence and circulating micronutrient levels in a low-income United States population. / Epplein, Meira; Signorello, Lisa B.; Zheng, Wei; Cai, Qiuyin; Hargreaves, Margaret K.; Michel, Angelika; Pawlita, Michael; Fowke, Jay; Correa, Pelayo; Blot, William J.

In: Cancer Prevention Research, Vol. 4, No. 6, 01.06.2011, p. 871-878.

Research output: Contribution to journalArticle

Epplein, M, Signorello, LB, Zheng, W, Cai, Q, Hargreaves, MK, Michel, A, Pawlita, M, Fowke, J, Correa, P & Blot, WJ 2011, 'Helicobacter pylori prevalence and circulating micronutrient levels in a low-income United States population', Cancer Prevention Research, vol. 4, no. 6, pp. 871-878. https://doi.org/10.1158/1940-6207.CAPR-10-0398
Epplein, Meira ; Signorello, Lisa B. ; Zheng, Wei ; Cai, Qiuyin ; Hargreaves, Margaret K. ; Michel, Angelika ; Pawlita, Michael ; Fowke, Jay ; Correa, Pelayo ; Blot, William J. / Helicobacter pylori prevalence and circulating micronutrient levels in a low-income United States population. In: Cancer Prevention Research. 2011 ; Vol. 4, No. 6. pp. 871-878.
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