Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets

Raffael Nachbagauer, Matthew S. Miller, Rong Hai, Alex Ryder, John K. Rose, Peter Palese, Adolfo García-Sastre, Florian Krammer, Randy A. Albrecht

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.

Original languageEnglish (US)
Pages (from-to)3268-3273
Number of pages6
JournalJournal of Virology
Volume90
Issue number6
DOIs
StatePublished - Jan 1 2016

Fingerprint

Ferrets
ferrets
virus transmission
Hemagglutinins
hemagglutinins
Orthomyxoviridae
Virus Replication
virus replication
Immunity
immunity
H1N1 Subtype Influenza A Virus
Influenza Vaccines
Virus Diseases
viral load
aerosols
Aerosols
Antibody Formation
Immunization
immunization
vaccines

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Nachbagauer, R., Miller, M. S., Hai, R., Ryder, A., Rose, J. K., Palese, P., ... Albrecht, R. A. (2016). Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets. Journal of Virology, 90(6), 3268-3273. https://doi.org/10.1128/JVI.02481-15

Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets. / Nachbagauer, Raffael; Miller, Matthew S.; Hai, Rong; Ryder, Alex; Rose, John K.; Palese, Peter; García-Sastre, Adolfo; Krammer, Florian; Albrecht, Randy A.

In: Journal of Virology, Vol. 90, No. 6, 01.01.2016, p. 3268-3273.

Research output: Contribution to journalArticle

Nachbagauer, R, Miller, MS, Hai, R, Ryder, A, Rose, JK, Palese, P, García-Sastre, A, Krammer, F & Albrecht, RA 2016, 'Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets', Journal of Virology, vol. 90, no. 6, pp. 3268-3273. https://doi.org/10.1128/JVI.02481-15
Nachbagauer, Raffael ; Miller, Matthew S. ; Hai, Rong ; Ryder, Alex ; Rose, John K. ; Palese, Peter ; García-Sastre, Adolfo ; Krammer, Florian ; Albrecht, Randy A. / Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets. In: Journal of Virology. 2016 ; Vol. 90, No. 6. pp. 3268-3273.
@article{d986294d60ae47e0878b0539779526f0,
title = "Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets",
abstract = "We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.",
author = "Raffael Nachbagauer and Miller, {Matthew S.} and Rong Hai and Alex Ryder and Rose, {John K.} and Peter Palese and Adolfo Garc{\'i}a-Sastre and Florian Krammer and Albrecht, {Randy A.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1128/JVI.02481-15",
language = "English (US)",
volume = "90",
pages = "3268--3273",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "6",

}

TY - JOUR

T1 - Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets

AU - Nachbagauer, Raffael

AU - Miller, Matthew S.

AU - Hai, Rong

AU - Ryder, Alex

AU - Rose, John K.

AU - Palese, Peter

AU - García-Sastre, Adolfo

AU - Krammer, Florian

AU - Albrecht, Randy A.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.

AB - We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.

UR - http://www.scopus.com/inward/record.url?scp=84961114525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961114525&partnerID=8YFLogxK

U2 - 10.1128/JVI.02481-15

DO - 10.1128/JVI.02481-15

M3 - Article

VL - 90

SP - 3268

EP - 3273

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 6

ER -