Hemodynamic effects of 1-[3,4-dihydroxypheny]-1,2-diaminoethane versus norepinephrine during ventricular fibrillation and cardiopulmonary resuscitation

Grace D. Nejman, Robert Griffith, Peter Van Ligten, James Hoekstra, Lynn Casto, Duane Miller, Charles G. Brown

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We hypothesized that substitution of the hydroxyl group (OH) on the beta carbon of norepinephrine (NE) with an amino group would yield a compound, 1-(3,4.dihydroxypheny)- 1,2-diaminoethane (DHPDAE), that would maintain the hemodynamic properties of NE during CPR, but would decrease the rate of post-defibrillation dysrhythmias. Six mixed breed swine weighing greater than 28 kg were studied. The animals were instrumented for cerebral (CBF) and myocardial blood flow (MBF) measurements. Ventricular fibrillation (VF) was induced. After 10 min of VF, CPR was begun. After 3 min of CPR, 2.5 mg/kg of DHPDAE was administered and CPR continued. Defibrillation was attempted 3.5 min after drug administration. CBF, MBF and defibrillation rates were compared to an historical control group receiving 0.16 mg/kg of NE. Outcome variables were compared using a Wilcoxon Rank Sum test and Fisher-exact test. NE significantly improved CBF and MBF compared to DHPDAE. All the animals in the NE group were successfully defibrillated into a perfusing rhythm. Sixty percent of the NE treated animals experienced post-defibrillation ventricular dysrhythmias. None of the animals in the DHPDAE were successfully defibrillated into a perfusing rhythm. Substitution of the hydroxyl group on the beta-carbon of NE with an amino group significantly decreases the hemodynamic properties of the parent molecule.

Original languageEnglish (US)
Pages (from-to)243-252
Number of pages10
JournalResuscitation
Volume20
Issue number3
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

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ethylenediamine
Cardiopulmonary Resuscitation
Ventricular Fibrillation
Norepinephrine
Hemodynamics
Nonparametric Statistics
Hydroxyl Radical
Carbon

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Nursing(all)

Cite this

Hemodynamic effects of 1-[3,4-dihydroxypheny]-1,2-diaminoethane versus norepinephrine during ventricular fibrillation and cardiopulmonary resuscitation. / Nejman, Grace D.; Griffith, Robert; Van Ligten, Peter; Hoekstra, James; Casto, Lynn; Miller, Duane; Brown, Charles G.

In: Resuscitation, Vol. 20, No. 3, 01.01.1990, p. 243-252.

Research output: Contribution to journalArticle

Nejman, Grace D. ; Griffith, Robert ; Van Ligten, Peter ; Hoekstra, James ; Casto, Lynn ; Miller, Duane ; Brown, Charles G. / Hemodynamic effects of 1-[3,4-dihydroxypheny]-1,2-diaminoethane versus norepinephrine during ventricular fibrillation and cardiopulmonary resuscitation. In: Resuscitation. 1990 ; Vol. 20, No. 3. pp. 243-252.
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abstract = "We hypothesized that substitution of the hydroxyl group (OH) on the beta carbon of norepinephrine (NE) with an amino group would yield a compound, 1-(3,4.dihydroxypheny)- 1,2-diaminoethane (DHPDAE), that would maintain the hemodynamic properties of NE during CPR, but would decrease the rate of post-defibrillation dysrhythmias. Six mixed breed swine weighing greater than 28 kg were studied. The animals were instrumented for cerebral (CBF) and myocardial blood flow (MBF) measurements. Ventricular fibrillation (VF) was induced. After 10 min of VF, CPR was begun. After 3 min of CPR, 2.5 mg/kg of DHPDAE was administered and CPR continued. Defibrillation was attempted 3.5 min after drug administration. CBF, MBF and defibrillation rates were compared to an historical control group receiving 0.16 mg/kg of NE. Outcome variables were compared using a Wilcoxon Rank Sum test and Fisher-exact test. NE significantly improved CBF and MBF compared to DHPDAE. All the animals in the NE group were successfully defibrillated into a perfusing rhythm. Sixty percent of the NE treated animals experienced post-defibrillation ventricular dysrhythmias. None of the animals in the DHPDAE were successfully defibrillated into a perfusing rhythm. Substitution of the hydroxyl group on the beta-carbon of NE with an amino group significantly decreases the hemodynamic properties of the parent molecule.",
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