Hemolytic uremic syndrome in an adolescent with Fusobacterium necrophorum bacteremia.

D. H. Chand, R. C. Brady, John Bissler

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Microorganisms may produce substances that disrupt the interaction between platelets and vascular endothelium, which has been associated with atypical hemolytic uremic syndrome (HUS). We present the first reported case of Fusobacterium necrophorum bacteremia that presented initially with atypical HUS. Antimicrobial therapy eradicated the patient's bacteremia, and plasmapheresis restored platelet-endothelial homeostasis. Understanding the pathophysiologic mechanisms involved in atypical HUS would guide the development of more precise therapies.

Original languageEnglish (US)
JournalAmerican journal of kidney diseases : the official journal of the National Kidney Foundation
Volume37
Issue number3
StatePublished - Jan 1 2001

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Fusobacterium necrophorum
Hemolytic-Uremic Syndrome
Bacteremia
Blood Platelets
Plasmapheresis
Vascular Endothelium
Homeostasis
Therapeutics
Atypical Hemolytic Uremic Syndrome

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

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abstract = "Microorganisms may produce substances that disrupt the interaction between platelets and vascular endothelium, which has been associated with atypical hemolytic uremic syndrome (HUS). We present the first reported case of Fusobacterium necrophorum bacteremia that presented initially with atypical HUS. Antimicrobial therapy eradicated the patient's bacteremia, and plasmapheresis restored platelet-endothelial homeostasis. Understanding the pathophysiologic mechanisms involved in atypical HUS would guide the development of more precise therapies.",
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AB - Microorganisms may produce substances that disrupt the interaction between platelets and vascular endothelium, which has been associated with atypical hemolytic uremic syndrome (HUS). We present the first reported case of Fusobacterium necrophorum bacteremia that presented initially with atypical HUS. Antimicrobial therapy eradicated the patient's bacteremia, and plasmapheresis restored platelet-endothelial homeostasis. Understanding the pathophysiologic mechanisms involved in atypical HUS would guide the development of more precise therapies.

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