Hepatic angiosarcoma and liver transplantation

Case report and literature review

Daniel Maluf, A. Cotterell, B. Clark, T. Stravitz, H. M. Kauffman, R. A. Fisher

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Hepatic angiosarcoma is a rare malignant vascular tumor that accounts for up to 2% of all primary liver tumors. Accurate diagnosis of this tumor is difficult, especially if the patient has no history of exposure to specific carcinogens including thorotrast, arsenicals, and vinyl chloride monomer. Diagnosis of diffuse angiosarcoma by means of liver biopsy has been reported as treacherous and nondiagnostic. Herein, we present a case of a 61-year-old Caucasian male with history of cryptogenic cirrhosis, normal alpha-fetoprotein, and pretransplant abnormal liver MRI who underwent nondiagnostic liver biopsies followed by liver transplantation. High grade diffuse angiosarcoma was diagnosed in the explanted liver. The patient developed bone metastases at 8 months and is alive 1 year posttransplantation. Diffuse liver tissue infiltration seen pretransplant on CT scan or MRI, suggesting the possibility of diffuse liver lesions (HCC, angiosarcoma, etc) must be fully investigated with all techniques available including multiple open liver biopsies to avoid the sacrifice of a liver allograft in these patients.

Original languageEnglish (US)
Pages (from-to)2195-2199
Number of pages5
JournalTransplantation Proceedings
Volume37
Issue number5
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

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Hemangiosarcoma
Liver Transplantation
Liver
Biopsy
Thorium Dioxide
Arsenicals
Vinyl Chloride
Neoplasms
alpha-Fetoproteins
Carcinogens
Allografts
Blood Vessels
Magnetic Resonance Imaging
Neoplasm Metastasis
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Hepatic angiosarcoma and liver transplantation : Case report and literature review. / Maluf, Daniel; Cotterell, A.; Clark, B.; Stravitz, T.; Kauffman, H. M.; Fisher, R. A.

In: Transplantation Proceedings, Vol. 37, No. 5, 01.01.2005, p. 2195-2199.

Research output: Contribution to journalArticle

Maluf, Daniel ; Cotterell, A. ; Clark, B. ; Stravitz, T. ; Kauffman, H. M. ; Fisher, R. A. / Hepatic angiosarcoma and liver transplantation : Case report and literature review. In: Transplantation Proceedings. 2005 ; Vol. 37, No. 5. pp. 2195-2199.
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