Hepatic artery thrombosis after liver transplantation and genetic factors

Prothrombin G20210A polymorphism

Valeria Mas, Robert A. Fisher, Daniel Maluf, David S. Wilkinson, Carleton T. Garrett, Andrea Ferreira-Gonzalez

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Hepatic artery thrombosis (HAT) after liver transplantation is associated with a high incidence of graft failure. The incidence ranges between 2% and 25%, with an overall incidence of approximately 7%. Different risk factors have been associated, but the participation of genetic factors in the cause of HAT is less well studied. A single-base change (G to A) at position 20210 in the 3′ untranslated region of the prothrombin gene is associated with increased plasma levels of prothrombin and might therefore increase the risk for thrombosis. We reviewed our HAT experience in 11 years at Medical College of Virginia hospitals of 491 patients undergoing 533 liver transplantations. There were 14 liver grafts with documented HAT (2.62%) in 13 patients. Prothrombin G20210A polymorphism was found in the DNA obtained from 2 of 14 liver allograft tissues (14.2%) but not in the DNA from leukocytes obtained from the peripheral blood of recipients with HAT.

Original languageEnglish (US)
Pages (from-to)247-249
Number of pages3
JournalTransplantation
Volume76
Issue number1
DOIs
StatePublished - Jul 15 2003

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Hepatic Artery
Prothrombin
Liver Transplantation
Thrombosis
Incidence
Transplants
Liver
DNA
3' Untranslated Regions
Allografts
Leukocytes
Genes

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Hepatic artery thrombosis after liver transplantation and genetic factors : Prothrombin G20210A polymorphism. / Mas, Valeria; Fisher, Robert A.; Maluf, Daniel; Wilkinson, David S.; Garrett, Carleton T.; Ferreira-Gonzalez, Andrea.

In: Transplantation, Vol. 76, No. 1, 15.07.2003, p. 247-249.

Research output: Contribution to journalArticle

Mas, Valeria ; Fisher, Robert A. ; Maluf, Daniel ; Wilkinson, David S. ; Garrett, Carleton T. ; Ferreira-Gonzalez, Andrea. / Hepatic artery thrombosis after liver transplantation and genetic factors : Prothrombin G20210A polymorphism. In: Transplantation. 2003 ; Vol. 76, No. 1. pp. 247-249.
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