Hepatic drug metabolism in critical illness

David S. McKindley, Scott Hanes, Bradley Boucher

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

Hepatic drug metabolism is altered in critically ill patients. The etiology and mechanisms of the alterations are not clearly understood and are difficult to address in clinical studies. For this reason, in vitro and animal models were developed to investigate the effects of critical illness on hepatic drug metabolism. Specifically, those with sepsis, septic shock, hemorrhagic shock, trauma, neurotrauma, and burns are populations that have been studied. Most of this research, however, has not led to established guidelines for the administration of drugs in these populations.

Original languageEnglish (US)
Pages (from-to)759-778
Number of pages20
JournalPharmacotherapy
Volume18
Issue number4
StatePublished - Jul 1 1998

Fingerprint

Critical Illness
Liver
Pharmaceutical Preparations
Hemorrhagic Shock
Septic Shock
Burns
Population
Sepsis
Animal Models
Guidelines
Wounds and Injuries
Research

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

McKindley, D. S., Hanes, S., & Boucher, B. (1998). Hepatic drug metabolism in critical illness. Pharmacotherapy, 18(4), 759-778.

Hepatic drug metabolism in critical illness. / McKindley, David S.; Hanes, Scott; Boucher, Bradley.

In: Pharmacotherapy, Vol. 18, No. 4, 01.07.1998, p. 759-778.

Research output: Contribution to journalReview article

McKindley, DS, Hanes, S & Boucher, B 1998, 'Hepatic drug metabolism in critical illness', Pharmacotherapy, vol. 18, no. 4, pp. 759-778.
McKindley DS, Hanes S, Boucher B. Hepatic drug metabolism in critical illness. Pharmacotherapy. 1998 Jul 1;18(4):759-778.
McKindley, David S. ; Hanes, Scott ; Boucher, Bradley. / Hepatic drug metabolism in critical illness. In: Pharmacotherapy. 1998 ; Vol. 18, No. 4. pp. 759-778.
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