Hepatic undifferentiated (embryonal) sarcoma arising in a mesenchymal hamartoma

Gregory Y. Lauwers, Larry D. Grant, William H. Donnelly, Aurelia M. Meloni, Robin M. Foss, Avery A. Sanberg, Max Langham

Research output: Contribution to journalArticle

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Abstract

We report the case of a hepatic undifferentiated (embryonal) sarcoma (UES) arising within a mesenchymal hamartoma (MH) in a 15-year-old girl. Mapping of the tumor demonstrated a typical MH transforming gradually into a UES composed of anaplastic stromal cells. When evaluated by flow cytometry, the MH was diploid and the UES showed a prominent aneuploid peak. Karyotypic analysis of the UES showed structural alterations of chromosome 19, which have been implicated as a potential genetic marker of MH. The histogenesis of MH and UES is still debated, and reports of a relationship between them, although suggested on the basis of histomorphologic similarities, have never been convincing. The histologic, flaw cytometric, and cytogenetic evidence reported herein suggests a link between these two hepatic tumors of the pediatric population.

Original languageEnglish (US)
Pages (from-to)1248-1254
Number of pages7
JournalAmerican Journal of Surgical Pathology
Volume21
Issue number10
DOIs
StatePublished - Oct 14 1997

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Hamartoma
Sarcoma
Liver
Chromosomes, Human, Pair 19
Aneuploidy
Stromal Cells
Diploidy
Genetic Markers
Cytogenetics
Neoplasms
Flow Cytometry
Pediatrics
Population

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Lauwers, G. Y., Grant, L. D., Donnelly, W. H., Meloni, A. M., Foss, R. M., Sanberg, A. A., & Langham, M. (1997). Hepatic undifferentiated (embryonal) sarcoma arising in a mesenchymal hamartoma. American Journal of Surgical Pathology, 21(10), 1248-1254. https://doi.org/10.1097/00000478-199710000-00018

Hepatic undifferentiated (embryonal) sarcoma arising in a mesenchymal hamartoma. / Lauwers, Gregory Y.; Grant, Larry D.; Donnelly, William H.; Meloni, Aurelia M.; Foss, Robin M.; Sanberg, Avery A.; Langham, Max.

In: American Journal of Surgical Pathology, Vol. 21, No. 10, 14.10.1997, p. 1248-1254.

Research output: Contribution to journalArticle

Lauwers, Gregory Y. ; Grant, Larry D. ; Donnelly, William H. ; Meloni, Aurelia M. ; Foss, Robin M. ; Sanberg, Avery A. ; Langham, Max. / Hepatic undifferentiated (embryonal) sarcoma arising in a mesenchymal hamartoma. In: American Journal of Surgical Pathology. 1997 ; Vol. 21, No. 10. pp. 1248-1254.
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AU - Sanberg, Avery A.

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