Hepatitis a virus 3C protease cleaves NEMO to impair induction of beta interferon

Dang Wang, Liurong Fang, Dahai Wei, Huan Zhang, Rui Luo, Huanchun Chen, Kui Li, Shaobo Xiao

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

NEMO (NF-κB essential modulator) is a bridging adaptor indispensable for viral activation of interferon (IFN) antiviral response. Herein, we show that hepatitis A virus (HAV) 3C protease (3Cpro) cleaves NEMO at the Q304 residue, negating its signaling adaptor function and abrogating viral induction of IFN-β synthesis via the retinoic acid-inducible gene I/melanoma differentiation-associated protein 5 (RIG-I/MDA5) and Toll-like receptor 3 (TLR3) pathways. NEMO cleavage and IFN antagonism, however, were lost upon ablation of the catalytic activity of 3Cpro. These data describe a novel immune evasion mechanism of HAV.

Original languageEnglish (US)
Pages (from-to)10252-10258
Number of pages7
JournalJournal of Virology
Volume88
Issue number17
DOIs
StatePublished - Jan 1 2014

Fingerprint

interferon-beta
Hepatitis Viruses
Interferon-beta
hepatitis
interferons
Interferons
Hepatitis A virus
proteinases
viruses
Toll-Like Receptor 3
immune evasion
Immune Evasion
Virus Activation
retinoic acid
melanoma
Tretinoin
catalytic activity
Antiviral Agents
synthesis
Genes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Wang, D., Fang, L., Wei, D., Zhang, H., Luo, R., Chen, H., ... Xiao, S. (2014). Hepatitis a virus 3C protease cleaves NEMO to impair induction of beta interferon. Journal of Virology, 88(17), 10252-10258. https://doi.org/10.1128/JVI.00869-14

Hepatitis a virus 3C protease cleaves NEMO to impair induction of beta interferon. / Wang, Dang; Fang, Liurong; Wei, Dahai; Zhang, Huan; Luo, Rui; Chen, Huanchun; Li, Kui; Xiao, Shaobo.

In: Journal of Virology, Vol. 88, No. 17, 01.01.2014, p. 10252-10258.

Research output: Contribution to journalArticle

Wang, D, Fang, L, Wei, D, Zhang, H, Luo, R, Chen, H, Li, K & Xiao, S 2014, 'Hepatitis a virus 3C protease cleaves NEMO to impair induction of beta interferon', Journal of Virology, vol. 88, no. 17, pp. 10252-10258. https://doi.org/10.1128/JVI.00869-14
Wang, Dang ; Fang, Liurong ; Wei, Dahai ; Zhang, Huan ; Luo, Rui ; Chen, Huanchun ; Li, Kui ; Xiao, Shaobo. / Hepatitis a virus 3C protease cleaves NEMO to impair induction of beta interferon. In: Journal of Virology. 2014 ; Vol. 88, No. 17. pp. 10252-10258.
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