Hepatitis C infection among survivors of childhood cancer

Donald K. Strickland, Caroline A. Riely, Christian C. Patrick, Dana Jones-Wallace, James M. Boyett, Bradford Waters, Jaquelyn Fitch Fleckenstein, Patrick J. Dean, Rene Davila, Tony E. Caver, Melissa M. Hudson

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Preliminary reports have suggested that survivors of childhood cancer and aplastic anemia who are infected with the hepatitis C virus (HCV) have a low risk for progression to significant liver disease. Among our surviving patients who were transfused between 1961 and March 1992, 77 (6.6% of surviving patients tested thus far) have evidence of HCV infection, whereas 4 surviving patients who were transfused after March 1992 are HCV-infected. One patient chronically infected with HCV died of liver failure, and 2 patients died of hepatocellular carcinoma. To characterize the risk for these and other complications, 65 patients are enrolled in a longitudinal study of HCV infection, of whom 58 (89.2%) had circulating HCV RNA at the time of protocol enrollment, with genotypes 1A and 1B most commonly isolated. Most enrolled patients have few or no symptoms, carry out normal activities, and have normal liver function. To date, 35 patients have undergone liver biopsy for abnormal liver function since the diagnosis of primary malignancy; central pathology review shows 28 (80%) have chronic active hepatitis, 25 (71%) have fibrosis, and 3 (9%) have cirrhosis. These preliminary data suggest that though most survivors of childhood cancer who are infected with HCV are clinically well, some are at risk for clinically significant liver disease. Identification of other HCV-infected patients and prospective monitoring of this cohort are ongoing to determine the risk for, and to identify factors associated with the progression of, liver disease. (C) 2000 by The American Society of Hematology.

Original languageEnglish (US)
Pages (from-to)3065-3070
Number of pages6
JournalBlood
Volume95
Issue number10
StatePublished - May 15 2000

Fingerprint

Hepatitis C
Viruses
Hepacivirus
Survivors
Liver
Infection
Neoplasms
Liver Diseases
Virus Diseases
Fibrosis
Aplastic Anemia
Biopsy
Liver Failure
Physiologic Monitoring
Pathology
Chronic Hepatitis
Longitudinal Studies
Hepatocellular Carcinoma
Genotype
RNA

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Strickland, D. K., Riely, C. A., Patrick, C. C., Jones-Wallace, D., Boyett, J. M., Waters, B., ... Hudson, M. M. (2000). Hepatitis C infection among survivors of childhood cancer. Blood, 95(10), 3065-3070.

Hepatitis C infection among survivors of childhood cancer. / Strickland, Donald K.; Riely, Caroline A.; Patrick, Christian C.; Jones-Wallace, Dana; Boyett, James M.; Waters, Bradford; Fleckenstein, Jaquelyn Fitch; Dean, Patrick J.; Davila, Rene; Caver, Tony E.; Hudson, Melissa M.

In: Blood, Vol. 95, No. 10, 15.05.2000, p. 3065-3070.

Research output: Contribution to journalArticle

Strickland, DK, Riely, CA, Patrick, CC, Jones-Wallace, D, Boyett, JM, Waters, B, Fleckenstein, JF, Dean, PJ, Davila, R, Caver, TE & Hudson, MM 2000, 'Hepatitis C infection among survivors of childhood cancer', Blood, vol. 95, no. 10, pp. 3065-3070.
Strickland DK, Riely CA, Patrick CC, Jones-Wallace D, Boyett JM, Waters B et al. Hepatitis C infection among survivors of childhood cancer. Blood. 2000 May 15;95(10):3065-3070.
Strickland, Donald K. ; Riely, Caroline A. ; Patrick, Christian C. ; Jones-Wallace, Dana ; Boyett, James M. ; Waters, Bradford ; Fleckenstein, Jaquelyn Fitch ; Dean, Patrick J. ; Davila, Rene ; Caver, Tony E. ; Hudson, Melissa M. / Hepatitis C infection among survivors of childhood cancer. In: Blood. 2000 ; Vol. 95, No. 10. pp. 3065-3070.
@article{ce8a11ff7f414aa09472a79a537267e6,
title = "Hepatitis C infection among survivors of childhood cancer",
abstract = "Preliminary reports have suggested that survivors of childhood cancer and aplastic anemia who are infected with the hepatitis C virus (HCV) have a low risk for progression to significant liver disease. Among our surviving patients who were transfused between 1961 and March 1992, 77 (6.6{\%} of surviving patients tested thus far) have evidence of HCV infection, whereas 4 surviving patients who were transfused after March 1992 are HCV-infected. One patient chronically infected with HCV died of liver failure, and 2 patients died of hepatocellular carcinoma. To characterize the risk for these and other complications, 65 patients are enrolled in a longitudinal study of HCV infection, of whom 58 (89.2{\%}) had circulating HCV RNA at the time of protocol enrollment, with genotypes 1A and 1B most commonly isolated. Most enrolled patients have few or no symptoms, carry out normal activities, and have normal liver function. To date, 35 patients have undergone liver biopsy for abnormal liver function since the diagnosis of primary malignancy; central pathology review shows 28 (80{\%}) have chronic active hepatitis, 25 (71{\%}) have fibrosis, and 3 (9{\%}) have cirrhosis. These preliminary data suggest that though most survivors of childhood cancer who are infected with HCV are clinically well, some are at risk for clinically significant liver disease. Identification of other HCV-infected patients and prospective monitoring of this cohort are ongoing to determine the risk for, and to identify factors associated with the progression of, liver disease. (C) 2000 by The American Society of Hematology.",
author = "Strickland, {Donald K.} and Riely, {Caroline A.} and Patrick, {Christian C.} and Dana Jones-Wallace and Boyett, {James M.} and Bradford Waters and Fleckenstein, {Jaquelyn Fitch} and Dean, {Patrick J.} and Rene Davila and Caver, {Tony E.} and Hudson, {Melissa M.}",
year = "2000",
month = "5",
day = "15",
language = "English (US)",
volume = "95",
pages = "3065--3070",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "10",

}

TY - JOUR

T1 - Hepatitis C infection among survivors of childhood cancer

AU - Strickland, Donald K.

AU - Riely, Caroline A.

AU - Patrick, Christian C.

AU - Jones-Wallace, Dana

AU - Boyett, James M.

AU - Waters, Bradford

AU - Fleckenstein, Jaquelyn Fitch

AU - Dean, Patrick J.

AU - Davila, Rene

AU - Caver, Tony E.

AU - Hudson, Melissa M.

PY - 2000/5/15

Y1 - 2000/5/15

N2 - Preliminary reports have suggested that survivors of childhood cancer and aplastic anemia who are infected with the hepatitis C virus (HCV) have a low risk for progression to significant liver disease. Among our surviving patients who were transfused between 1961 and March 1992, 77 (6.6% of surviving patients tested thus far) have evidence of HCV infection, whereas 4 surviving patients who were transfused after March 1992 are HCV-infected. One patient chronically infected with HCV died of liver failure, and 2 patients died of hepatocellular carcinoma. To characterize the risk for these and other complications, 65 patients are enrolled in a longitudinal study of HCV infection, of whom 58 (89.2%) had circulating HCV RNA at the time of protocol enrollment, with genotypes 1A and 1B most commonly isolated. Most enrolled patients have few or no symptoms, carry out normal activities, and have normal liver function. To date, 35 patients have undergone liver biopsy for abnormal liver function since the diagnosis of primary malignancy; central pathology review shows 28 (80%) have chronic active hepatitis, 25 (71%) have fibrosis, and 3 (9%) have cirrhosis. These preliminary data suggest that though most survivors of childhood cancer who are infected with HCV are clinically well, some are at risk for clinically significant liver disease. Identification of other HCV-infected patients and prospective monitoring of this cohort are ongoing to determine the risk for, and to identify factors associated with the progression of, liver disease. (C) 2000 by The American Society of Hematology.

AB - Preliminary reports have suggested that survivors of childhood cancer and aplastic anemia who are infected with the hepatitis C virus (HCV) have a low risk for progression to significant liver disease. Among our surviving patients who were transfused between 1961 and March 1992, 77 (6.6% of surviving patients tested thus far) have evidence of HCV infection, whereas 4 surviving patients who were transfused after March 1992 are HCV-infected. One patient chronically infected with HCV died of liver failure, and 2 patients died of hepatocellular carcinoma. To characterize the risk for these and other complications, 65 patients are enrolled in a longitudinal study of HCV infection, of whom 58 (89.2%) had circulating HCV RNA at the time of protocol enrollment, with genotypes 1A and 1B most commonly isolated. Most enrolled patients have few or no symptoms, carry out normal activities, and have normal liver function. To date, 35 patients have undergone liver biopsy for abnormal liver function since the diagnosis of primary malignancy; central pathology review shows 28 (80%) have chronic active hepatitis, 25 (71%) have fibrosis, and 3 (9%) have cirrhosis. These preliminary data suggest that though most survivors of childhood cancer who are infected with HCV are clinically well, some are at risk for clinically significant liver disease. Identification of other HCV-infected patients and prospective monitoring of this cohort are ongoing to determine the risk for, and to identify factors associated with the progression of, liver disease. (C) 2000 by The American Society of Hematology.

UR - http://www.scopus.com/inward/record.url?scp=18744419247&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18744419247&partnerID=8YFLogxK

M3 - Article

VL - 95

SP - 3065

EP - 3070

JO - Blood

JF - Blood

SN - 0006-4971

IS - 10

ER -