Hepatitis C virus and antiviral innate immunity

Who wins at tug-of-war?

Da Rong Yang, Hai Zhen Zhu

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) is a major human pathogen of chronic hepatitis and related liver diseases. Innate immunity is the first line of defense against invading foreign pathogens, and its activation is dependent on the recognition of these pathogens by several key sensors. The interferon (IFN) system plays an essential role in the restriction of HCV infection via the induction of hundreds of IFN-stimulated genes (ISGs) that inhibit viral replication and spread. However, numerous factors that trigger immune dysregulation, including viral factors and host genetic factors, can help HCV to escape host immune response, facilitating viral persistence. In this review, we aim to summarize recent advances in understanding the innate immune response to HCV infection and the mechanisms of ISGs to suppress viral survival, as well as the immune evasion strategies for chronic HCV infection.

Original languageEnglish (US)
Pages (from-to)3786-3800
Number of pages15
JournalWorld Journal of Gastroenterology
Volume21
Issue number13
DOIs
StatePublished - Apr 7 2015

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Innate Immunity
Hepacivirus
Antiviral Agents
Virus Diseases
Interferons
Immune Evasion
Viral Genes
Immunologic Factors
Chronic Hepatitis C
Chronic Hepatitis
Liver Diseases
Warfare
Survival
Genes

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Hepatitis C virus and antiviral innate immunity : Who wins at tug-of-war? / Yang, Da Rong; Zhu, Hai Zhen.

In: World Journal of Gastroenterology, Vol. 21, No. 13, 07.04.2015, p. 3786-3800.

Research output: Contribution to journalReview article

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