Hepatitis C virus-related thrombocytopenia

Clinical and laboratory characteristics compared with chronic immune thrombocytopenic purpura

Sandeep Rajan, Byron M. Espina, Howard A. Liebman

Research output: Contribution to journalArticle

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Abstract

Thrombocytopenia can be a complication of hepatitis C viral (HCV) infection. However, there is little published data regarding the clinical and laboratory manifestations of HCV-related thrombocytopenia (HCV-TP) compared with adult chronic immune thrombocytopenic purpura (CITP). We reviewed the medical records for all patients evaluated for chronic thrombocytopenia by the Haematology Service between January 1996 and June 2000. All patients were screened for HCV infection at the time of initial diagnosis. Of 250 patients who fulfilled American Society of Hematology criteria for CITP, 76 (30%) were HCV seropositive. HCV-TP patients were older [mean age (±SD) 54.9 ± 8 years vs. 40.3 ± 8 years, P ≤ 0.001] and equally distributed between both sexes. HCV-TP patients had less severe thrombocytopenia, defined as platelet count ≤10 × 109/l (4% vs. 46% for CITP, P ≤ 0.001). However, 56 (74%) had a platelet count ≤50 × 109/l. Symptoms and signs of thrombocytopenia were less frequent in HCV-TP, but major bleeding was more frequent (25% vs. 10%, P = 0.0059). Serum cryoglobulins and anticardiolipin antibodies were more frequent in HCV-TP (90% and 62% respectively), but rare in CITP (7% and 15%, P ≤ 0.001 compared with HCV-TP). HCV infection can be associated with significant thrombocytopenia and appears to be a distinct clinical entity.

Original languageEnglish (US)
Pages (from-to)818-824
Number of pages7
JournalBritish Journal of Haematology
Volume129
Issue number6
DOIs
StatePublished - Jun 1 2005

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Idiopathic Thrombocytopenic Purpura
Hepatitis C
Hepacivirus
Thrombocytopenia
Virus Diseases
Platelet Count
Cryoglobulins
Anticardiolipin Antibodies
Hematology
Signs and Symptoms
Medical Records
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Hematology

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Hepatitis C virus-related thrombocytopenia : Clinical and laboratory characteristics compared with chronic immune thrombocytopenic purpura. / Rajan, Sandeep; Espina, Byron M.; Liebman, Howard A.

In: British Journal of Haematology, Vol. 129, No. 6, 01.06.2005, p. 818-824.

Research output: Contribution to journalArticle

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