Hepatocellular carcinoma in HCV-infected patients awaiting liver transplantation

Genes involved in tumor progression

Valeria Mas, Daniel Maluf, Richard Stravitz, Catherine I. Dumur, Bradly Clark, Cheryl Rodgers, Andrea Ferreira-Gonzalez, Robert A. Fisher

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer death in the world. The present study aimed to investigate the genes involved in viral carcinogenesis and tumor progression in liver transplant recipients with hepatitis C virus (HCV) and HCC. To accomplish this, we performed the analysis of hepatic gene expression in HCV-infected liver recipient patients with stages of disease ranging from early cirrhosis with preserved volume and function to late cirrhosis with diminished volume and function with and without HCC. We found consistent differences between the gene expression patterns in HCV-HCC and those of early HCV-cirrhosis, late HCV cirrhosis, and normal control livers. The expression patterns in HCC were also readily distinguished between early and advanced HCC tumor stages. Moreover, we found different gene expression patterns between early cirrhosis and late cirrhosis. In conclusion, these findings confirm the presence of multiple molecular alterations during HCV-HCC hepatocarcinogenesis and, clinically, indicate the possibility for identifying prognostic factors associated with HCC progression in liver transplant patients waiting for a donor and/or posttransplantation recurrence.

Original languageEnglish (US)
Pages (from-to)607-620
Number of pages14
JournalLiver Transplantation
Volume10
Issue number5
DOIs
StatePublished - May 1 2004
Externally publishedYes

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Hepacivirus
Liver Transplantation
Hepatocellular Carcinoma
Fibrosis
Genes
Neoplasms
Liver
Gene Expression
Cause of Death
Carcinogenesis
Tissue Donors
Transplants
Recurrence

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Hepatocellular carcinoma in HCV-infected patients awaiting liver transplantation : Genes involved in tumor progression. / Mas, Valeria; Maluf, Daniel; Stravitz, Richard; Dumur, Catherine I.; Clark, Bradly; Rodgers, Cheryl; Ferreira-Gonzalez, Andrea; Fisher, Robert A.

In: Liver Transplantation, Vol. 10, No. 5, 01.05.2004, p. 607-620.

Research output: Contribution to journalArticle

Mas, Valeria ; Maluf, Daniel ; Stravitz, Richard ; Dumur, Catherine I. ; Clark, Bradly ; Rodgers, Cheryl ; Ferreira-Gonzalez, Andrea ; Fisher, Robert A. / Hepatocellular carcinoma in HCV-infected patients awaiting liver transplantation : Genes involved in tumor progression. In: Liver Transplantation. 2004 ; Vol. 10, No. 5. pp. 607-620.
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