Heritability of blood pressure responses to cold pressor test in a chinese population

Hao Mei, Dongfeng Gu, Treva K. Rice, James E. Hixson, Jing Chen, Cashell E. Jaquish, Qi Zhao, Chung Shiuan Chen, Ji Chun Chen, C. Charles Gu, Tanika N. Kelly, Jiang He

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Abstract

BackgroundGenetic determinants of blood pressure (BP) responses to the cold pressor test (CPT), a phenotype associated with risk of hypertension and cardiovascular disease has not been well studied.MethodsWe examined the heritability of BP response to CPT in 1,994 subjects from 627 families in rural north China. BP was measured before and at 0, 1, 2, and 4 min after the participants immersed their hand in ice water for 1 min. Heritabilities of baseline BP and responses at 0 min, maximum response, and area-under-the-curve (AUC) during CPT were computed using a variance components method. Additionally, bivariate heritabilities were calculated to test the existence of shared genetic determinants between baseline BP and responses to CPT. ResultsHeritabilities of baseline BP and responses to CPT were estimated from 14 to 35%, which all significantly differed from 0 (P 0.002). Genetic correlations (s.e.) due to the same genes between baseline BP and responses to CPT ranged from 0.07 (0.14) to 0.21 (0.15), which were not significantly different from 0. Genetic correlations between reactivity and recovery were 0.67 (0.10) and 0.59 (0.10) for systolic (SBP) and diastolic BP (DBP), respectively, which were significantly different from 0.ConclusionsWe concluded that (i) baseline BP and BP responses to CPT had strong genetic determinants; (ii) baseline BP and BP response to CPT did not share the same genetic components; and (iii) BP reactivity and recovery shared the same genetic components. These findings may lead to a better understanding of the genetic mechanism of BP responses to CPT.

Original languageEnglish (US)
Pages (from-to)1096-1100
Number of pages5
JournalAmerican journal of hypertension
Volume22
Issue number10
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

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Blood Pressure
Population
Ice
Area Under Curve
China
Cardiovascular Diseases
Hand
Hypertension
Phenotype
Water

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Mei, H., Gu, D., Rice, T. K., Hixson, J. E., Chen, J., Jaquish, C. E., ... He, J. (2009). Heritability of blood pressure responses to cold pressor test in a chinese population. American journal of hypertension, 22(10), 1096-1100. https://doi.org/10.1038/ajh.2009.139

Heritability of blood pressure responses to cold pressor test in a chinese population. / Mei, Hao; Gu, Dongfeng; Rice, Treva K.; Hixson, James E.; Chen, Jing; Jaquish, Cashell E.; Zhao, Qi; Chen, Chung Shiuan; Chen, Ji Chun; Gu, C. Charles; Kelly, Tanika N.; He, Jiang.

In: American journal of hypertension, Vol. 22, No. 10, 01.10.2009, p. 1096-1100.

Research output: Contribution to journalArticle

Mei, H, Gu, D, Rice, TK, Hixson, JE, Chen, J, Jaquish, CE, Zhao, Q, Chen, CS, Chen, JC, Gu, CC, Kelly, TN & He, J 2009, 'Heritability of blood pressure responses to cold pressor test in a chinese population', American journal of hypertension, vol. 22, no. 10, pp. 1096-1100. https://doi.org/10.1038/ajh.2009.139
Mei, Hao ; Gu, Dongfeng ; Rice, Treva K. ; Hixson, James E. ; Chen, Jing ; Jaquish, Cashell E. ; Zhao, Qi ; Chen, Chung Shiuan ; Chen, Ji Chun ; Gu, C. Charles ; Kelly, Tanika N. ; He, Jiang. / Heritability of blood pressure responses to cold pressor test in a chinese population. In: American journal of hypertension. 2009 ; Vol. 22, No. 10. pp. 1096-1100.
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abstract = "BackgroundGenetic determinants of blood pressure (BP) responses to the cold pressor test (CPT), a phenotype associated with risk of hypertension and cardiovascular disease has not been well studied.MethodsWe examined the heritability of BP response to CPT in 1,994 subjects from 627 families in rural north China. BP was measured before and at 0, 1, 2, and 4 min after the participants immersed their hand in ice water for 1 min. Heritabilities of baseline BP and responses at 0 min, maximum response, and area-under-the-curve (AUC) during CPT were computed using a variance components method. Additionally, bivariate heritabilities were calculated to test the existence of shared genetic determinants between baseline BP and responses to CPT. ResultsHeritabilities of baseline BP and responses to CPT were estimated from 14 to 35{\%}, which all significantly differed from 0 (P 0.002). Genetic correlations (s.e.) due to the same genes between baseline BP and responses to CPT ranged from 0.07 (0.14) to 0.21 (0.15), which were not significantly different from 0. Genetic correlations between reactivity and recovery were 0.67 (0.10) and 0.59 (0.10) for systolic (SBP) and diastolic BP (DBP), respectively, which were significantly different from 0.ConclusionsWe concluded that (i) baseline BP and BP responses to CPT had strong genetic determinants; (ii) baseline BP and BP response to CPT did not share the same genetic components; and (iii) BP reactivity and recovery shared the same genetic components. These findings may lead to a better understanding of the genetic mechanism of BP responses to CPT.",
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AU - Rice, Treva K.

AU - Hixson, James E.

AU - Chen, Jing

AU - Jaquish, Cashell E.

AU - Zhao, Qi

AU - Chen, Chung Shiuan

AU - Chen, Ji Chun

AU - Gu, C. Charles

AU - Kelly, Tanika N.

AU - He, Jiang

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N2 - BackgroundGenetic determinants of blood pressure (BP) responses to the cold pressor test (CPT), a phenotype associated with risk of hypertension and cardiovascular disease has not been well studied.MethodsWe examined the heritability of BP response to CPT in 1,994 subjects from 627 families in rural north China. BP was measured before and at 0, 1, 2, and 4 min after the participants immersed their hand in ice water for 1 min. Heritabilities of baseline BP and responses at 0 min, maximum response, and area-under-the-curve (AUC) during CPT were computed using a variance components method. Additionally, bivariate heritabilities were calculated to test the existence of shared genetic determinants between baseline BP and responses to CPT. ResultsHeritabilities of baseline BP and responses to CPT were estimated from 14 to 35%, which all significantly differed from 0 (P 0.002). Genetic correlations (s.e.) due to the same genes between baseline BP and responses to CPT ranged from 0.07 (0.14) to 0.21 (0.15), which were not significantly different from 0. Genetic correlations between reactivity and recovery were 0.67 (0.10) and 0.59 (0.10) for systolic (SBP) and diastolic BP (DBP), respectively, which were significantly different from 0.ConclusionsWe concluded that (i) baseline BP and BP responses to CPT had strong genetic determinants; (ii) baseline BP and BP response to CPT did not share the same genetic components; and (iii) BP reactivity and recovery shared the same genetic components. These findings may lead to a better understanding of the genetic mechanism of BP responses to CPT.

AB - BackgroundGenetic determinants of blood pressure (BP) responses to the cold pressor test (CPT), a phenotype associated with risk of hypertension and cardiovascular disease has not been well studied.MethodsWe examined the heritability of BP response to CPT in 1,994 subjects from 627 families in rural north China. BP was measured before and at 0, 1, 2, and 4 min after the participants immersed their hand in ice water for 1 min. Heritabilities of baseline BP and responses at 0 min, maximum response, and area-under-the-curve (AUC) during CPT were computed using a variance components method. Additionally, bivariate heritabilities were calculated to test the existence of shared genetic determinants between baseline BP and responses to CPT. ResultsHeritabilities of baseline BP and responses to CPT were estimated from 14 to 35%, which all significantly differed from 0 (P 0.002). Genetic correlations (s.e.) due to the same genes between baseline BP and responses to CPT ranged from 0.07 (0.14) to 0.21 (0.15), which were not significantly different from 0. Genetic correlations between reactivity and recovery were 0.67 (0.10) and 0.59 (0.10) for systolic (SBP) and diastolic BP (DBP), respectively, which were significantly different from 0.ConclusionsWe concluded that (i) baseline BP and BP responses to CPT had strong genetic determinants; (ii) baseline BP and BP response to CPT did not share the same genetic components; and (iii) BP reactivity and recovery shared the same genetic components. These findings may lead to a better understanding of the genetic mechanism of BP responses to CPT.

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